Evidence map›Paper›PMID 30344281›Full record

ReviewMedicina (Kaunas, Lithuania)2018

Human Papilloma Virus (HPV) and Fertilization: A Mini Review.

Konstantinos Zacharis, Christina I Messini, George Anifandis, George Koukoulis, Maria Satra, Alexandros Daponte

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07320183 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of a Dietary Supplement Containing EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid in Supporting Male Genital Balance in Subjects Exposed to HPV Risk

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled96ConditionsHPV - Anogenital Human Papilloma Virus Infection, InfertilitiesArmspervistop
NCT07344337 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection.

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2028Enrolled96ConditionsHPV Infection, InfertilitiesArmsPervistop
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. HPV-related diseases in male patients: an underestimated conundrum.Journal of endocrinological investigation · 2024
    Review
  10. Article
  11. Human Papillomavirus and Male Infertility: What Do We Know?International journal of molecular sciences · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Epidemiology and infection · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Konstantinos ZacharisSchool of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. zaxarisk@yahoo.com.ORCID 0000-0002-3076-818X
Christina I MessiniSchool of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. pireaschristina@gmail.com.ORCID 0000-0002-0909-2365
George AnifandisSchool of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. ganif@med.uth.gr.
George KoukoulisSchool of Health Sciences, Faculty of Medicine, Department of Morphology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. geokoukoulis@gmail.com.
Maria SatraSchool of Health Sciences, Faculty of Medicine, Department of Biology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. msatra@med.uth.gr.
Alexandros DaponteSchool of Health Sciences, Faculty of Medicine, Department of Obstetrics and Gynaecology, University of Thessaly, Biopolis, T.K., 42200 Larissa, Greece. adaponte@gmail.com.
University of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papilloma virus (HPV) is one of the most prevalent viral sexually transmitted diseases. The ability of HPV to induce malignancy in the anogenital tract and stomato-pharyngeal cavity is well documented. Moreover, HPV infection may also affect reproductive health and fertility. Although, the impact of HPV on female fertility has not been thoroughly studied it has been found also to have an impact on semen parameters. Relative information can be obtained from studies investigating the relationship between HPV and pregnancy success. Furthermore, there is an ongoing debate whether HPV alters the efficacy of assisted reproductive technologies. An association between HPV and assisted reproductive technologies (ART) programs has been reported. Nevertheless, due to conflicting data and the small number of existing studies further research is required. It remains to be clarified whether HPV detection and genotyping could be included in the diagnostic procedures in couples undergoing in vitro fertilization (IVF)/intrauterine insemination (IUI) treatments. Vaccination of both genders against HPV can reduce the prevalence of HPV infection and eliminate its implications on human fertility. The aim of the present mini-review is to reiterate the association between HPV and human fertility through a systematic literature review.

Indexed as

FertilityPapillomaviridaeReproductive Techniques, AssistedFemaleHumansInfertilityMalePapillomavirus InfectionsPregnancyassisted reproductive technologycryopreservationfertilityHPVIVFsemen

Identifiers

PMID30344281
PMCPMC6174353
OpenAlexW2750937645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.