Observational studyJournal of epidemiology2019
The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study.
Observational study in Journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01727518 (The Austrian LEAD), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Austrian LEAD (Lung hEart sociAl boDy) Study
Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Low SARS-CoV-2 seroprevalence in the Austrian capital after an early governmental lockdown.Scientific reports · 2021Trial
- [Implementation of a national lung cancer screening in Austria : Position paper of the Austrian Radiological Society (ÖRG), the Austrian Society of Pneumology (ÖGP), the Austrian Society of General Practice and Family Medicine (ÖGAM) and the Austrian Society of Thoracic Surgery (ÖGTC)].Wiener klinische Wochenschrift · 2026Article
- Explainable age prediction using a transformer trained on diverse global electrocardiograms.European heart journal. Digital health · 2026Article
- Prevalence and potential associations of the 2022 newly introduced monocyte value for diagnosis of chronic myelomonocytic leukemia in a general Austrian population.Wiener medizinische Wochenschrift (1946) · 2026Article
- Temporal Patterns of Allergen Sensitisation in the General Population: The LEAD Study.Clinical and translational allergy · 2026Article
- Association of triglyceride-glucose index with presence and development of impaired spirometry: results from Austrian LEAD cohort.BMC pulmonary medicine · 2026Article
- Integration of lung function in allostatic load scoring and its impact on mortality prediction.Scientific reports · 2026Article
- Article
- Physiological characteristics and temporal transitions of preserved ratio impaired spirometry.ERJ open research · 2026Article
- Prevalence and determinants of vascular aging in Austria - a holistic view: the LEAD study.Journal of hypertension · 2026Observational
- Prevalence and Spirometric Transitions of PRISm and Obstruction: A Population-Based Study.Respirology (Carlton, Vic.) · 2026Article
- Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities.Nature reviews. Drug discovery · 2026Review
- Nonlinear thresholds in lipid-frailty interplay: Precision targets for severe airflow limitation in aging adults.PloS one · 2026Article
- Article
- Reference equations for oscillometry in adults: data from the Austrian LEAD study.ERJ open research · 2026Article
- The contribution of depression and anxiety to frailty in men and women: data from a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- Longitudinal variability of blood eosinophils impact lung function decline in the general population.ERJ open research · 2025Article
- Refining mild asthma phenotyping with FeNO: a population-based evaluation.NPJ primary care respiratory medicine · 2025Article
- Comparison of usability and user-friendliness of three FeNO analyzers in a general population cohort of the LEAD study.Scientific reports · 2025Article
- Incidence of Prediabetes and Diabetes in a European Longitudinal General Population Cohort and Its Associated Factors-Results From the Austrian LEAD Study.Journal of diabetes research · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Lung, hEart, sociAl, boDy (LEAD) Study (ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov) is a longitudinal, observational, population-based Austrian cohort that aims to investigate the relationship between genetic, environmental, social, developmental and ageing factors influencing respiratory health and comorbidities through life. The general working hypothesis of LEAD is the interaction of these genetic, environmental and socioeconomic factors influences lung development and ageing, the risk of occurrence of several non-communicable diseases (respiratory, cardiovascular, metabolic and neurologic), as well as their phenotypic (ie, clinical) presentation.
methodsLEAD invited from 2011-2016 a random sample (stratified by age, gender, residential area) of Vienna inhabitants (urban cohort) and all the inhabitants of six villages from Lower Austria (rural cohort). Participants will be followed-up every four years. A number of investigations and measurements were obtained in each of the four domains of the study (Lung, hEart, sociAl, boDy) including data to screen for lung, cardiovascular and metabolic diseases, osteoporosis, and cognitive function. Blood and urine samples are stored in a biobank for future investigations.
resultsA total of 11.423 males (47.6%) and females (52.4%), aged 6-80 years have been included in the cohort. Compared to governmental statistics, the external validity of LEAD with respect to age, gender, citizenship, and smoking status was high.
conclusionsIn conclusion, the LEAD cohort has been established following high quality standards; it is representative of the Austrian population and offers a platform to understand lung development and ageing as a key mechanism of human health both in early and late adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.