Evidence map›Paper›PMID 30344041›Full record

ArticleNeuron2018

Molecular Interface of Neuronal Innate Immunity, Synaptic Vesicle Stabilization, and Presynaptic Homeostatic Plasticity.

Nathan Harris, Richard D Fetter, Daniel J Brasier, Amy Tong, Graeme W Davis

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06263361 (Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06263361 recruitingnot on this mapstarted 2021, after this paper: background citation

Improving Safety and Accuracy of Stereotactic Brain Biopsies in Primary Central Nervous System Lymphoma (PCNSL): Integration of Advanced MRI Patterns and Fluorescein Sodium Fluorescence

TypeobservationalSponsorIRCCS San RaffaeleRan2021 to 2029Enrolled15ConditionsCerebral LymphomaArmsMRI imaging, Cerebral biopsy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  8. Bacteria-Derived Peptidoglycan Triggers a Noncanonical Nuclear Factor-κB-Dependent Response inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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  11. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nathan HarrisDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Richard D FetterDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Daniel J BrasierDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Amy TongDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
Graeme W DavisDepartment of Biochemistry and Biophysics, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: graeme.davis@ucsf.edu.
University of California, San Francisco · US

Funding

Homeostatic Stabilization of Neural Function in Health and DiseaseR35NS097212 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVIS, GRAEME W · 2017 to 2024
$9.2M
NINDS NIH HHS R35 NS097212
6 · The paper itself

Abstract

We define a homeostatic function for innate immune signaling within neurons. A genetic analysis of the innate immune signaling genes IMD, IKKβ, Tak1, and Relish demonstrates that each is essential for presynaptic homeostatic plasticity (PHP). Subsequent analyses define how the rapid induction of PHP (occurring in seconds) can be coordinated with the life-long maintenance of PHP, a time course that is conserved from invertebrates to mammals. We define a novel bifurcation of presynaptic innate immune signaling. Tak1 (Map3K) acts locally and is selective for rapid PHP induction. IMD, IKKβ, and Relish are essential for long-term PHP maintenance. We then define how Tak1 controls vesicle release. Tak1 stabilizes the docked vesicle state, which is essential for the homeostatic expansion of the readily releasable vesicle pool. This represents a mechanism for the control of vesicle release, and an interface of innate immune signaling with the vesicle fusion apparatus and homeostatic plasticity.

Indexed as

HomeostasisImmunity, InnateAnimalsAnimals, Genetically ModifiedDrosophila melanogasterDrosophila ProteinsFemaleI-kappa B KinaseMaleMAP Kinase Kinase KinasesNeuronal PlasticityNeuronsPresynaptic TerminalsSignal TransductionSynaptic VesiclesTranscription FactorsDrosophila ProteinsI-kappa B KinaseIKKbeta protein, Drosophilaimd protein, DrosophilaMAP Kinase Kinase KinasesRel protein, DrosophilaTAK1 protein, DrosophilaTranscription FactorsdockingDrosophilahomeostatic plasticityIKKinnate immunitymotoneuronmotor neuronNMJpresynaptic releaseprimingreadily releasable poolRelsynapsesynaptic vesicleTak1vesicle

Identifiers

PMID30344041
PMCPMC6283688
OpenAlexW2897016104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.