ArticleCell host & microbe2018
SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Resting Memory CD4+ T Cells.
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Article in Cell host & microbe, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
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Who cites it
57 citing papers in PubMed, 79 citations in OpenAlex.
- Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.Immunologic research · 2026Review
- RIPK3/SQSTM1-Mediated Necroptosis Activates the NLRP3 Inflammasome in Dry Eye Disease.Investigative ophthalmology & visual science · 2026Article
- Methaneseleninic acid, a circadian-modulating agent, reactivates latent HIV-1 infection without cellular activation or proliferation.Journal of virology · 2026Article
- Article
- Host-directed approaches in the pursuit of a cure for HIV.Antiviral research · 2025Review
- The inducible role of autophagy in cell death: emerging evidence and future perspectives.Cell communication and signaling : CCS · 2025Review
- ABT-263, a BCL-2 inhibitor, selectively eliminates latently HIV-1-infected cells without viral reactivation.PloS one · 2025Article
- SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death.Frontiers in immunology · 2025Article
- Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice.iScience · 2024Article
- A Microenvironment-Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti-Infection and Osteo-Immune Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- KDM5A/B contribute to HIV-1 latent infection and survival of HIV-1 infected cells.Antiviral research · 2024Article
- Review
- Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection.Nature communications · 2024Article
- HIV-1 Vpr Functions in Primary CD4Viruses · 2024Review
- Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells.Pathogens & immunity · 2024Article
- Review
- Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure.Viruses · 2023Review
- Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice.Cell reports. Medicine · 2023Article
- Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.Nature structural & molecular biology · 2023Article
- HIV-1 Tat Upregulates TREM1 Expression in Human Microglia.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Grant R CampbellDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Rachel S BruckmanDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Yen-Lin ChuDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Rodney N TroutDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Stephen A SpectorDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address: saspector@ucsd.edu.
University of California, San Diego · US
Funding
LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Jennifer Jao, Sharon A Nachman · 2011 to 2026
$278.1MStatistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6MValidation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8MVirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4MLC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2MUniversity of California, San Diego Clinical Trial UnitUM1AI069536 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEPHEN A SPECTOR · 2012 to 2026
$34.0MHost Genetic Factors Associated with CNS Disease of HIV-Infected ChildrenR01NS077874 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2011 to 2015
$3.6MNanopeptide Targeting of HIV-CNS Reservoirs without ReactivationR01NS104015 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2017 to 2021
$2.9MModulating Autophagy to Eradicate HIV-1 from CNS ReservoirsR01NS084912 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2013 to 2017
$1.9MNIAID NIH HHS P30 AI036214NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI069536NIAID NIH HHS UM1 AI106701NIAID NIH HHS UM1 AI106716NINDS NIH HHS R01 NS077874NINDS NIH HHS R01 NS084912NINDS NIH HHS R01 NS104015
Abstract
Long-lived resting memory CD4+ T cells (T
Indexed as
ApoptosisApoptosis Regulatory ProteinsAutophagyAutophagy-Related Protein 5Autophagy-Related Protein 7Baculoviral IAP Repeat-Containing 3 ProteinBeclin-1BenzoquinonesCaspase 8CD4-Positive T-LymphocytesCell DeathCell LineCyclohexanesDipeptidesFas-Associated Death Domain ProteinHIV-1Apoptosis Regulatory ProteinsATG5 protein, humanATG7 protein, humanAutophagy-Related Protein 5Autophagy-Related Protein 7Baculoviral IAP Repeat-Containing 3 ProteinBeclin-1BenzoquinonesBIRC2 protein, humanBIRC3 protein, humanbirinapantCaspase 8CyclohexanesDIABLO protein, humanDipeptidesembelinFADD protein, humanFas-Associated Death Domain ProteinGDC-0152IndolesInhibitor of Apoptosis ProteinsIntracellular Signaling Peptides and ProteinsMitochondrial ProteinsPyrrolesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanRIPK3 protein, humanSequestosome-1 ProteinSQSTM1 protein, humanUbiquitin-Protein LigasesXIAP protein, humanX-Linked Inhibitor of Apoptosis ProteinapoptosisautophagyBIRC2caspase 8CD4+ T cellFasHIVRIPK1SMAC mimeticsXIAP
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.