ReviewAtherosclerosis2019
Nature and nurture of tissue-specific macrophage phenotypes.
Review in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Tissue signatures of human macrophages during homeostasis and activation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- OxLDL drives pro-inflammatory and foam cell-prone macrophage reprogramming via NF-κB/HIF-1β-dependent metabolic rewiring.Frontiers in cardiovascular medicine · 2026Article
- Systematic characterization of existing and novel inducible transgenic systems in human pluripotent stem cells after prolonged differentiation.bioRxiv : the preprint server for biology · 2025Article
- Macrophage Development and Function.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Epigenomic regulation of macrophage polarization: Where do the nuclear receptors belong?Immunological reviews · 2023Review
- Review
- Editorial: Transcriptional regulation of macrophage function.Frontiers in immunology · 2023Article
- Exploring the signal-dependent transcriptional regulation involved in the liver pathology of type 2 diabetes.Diabetology international · 2023Review
- Improved Macrophage Enrichment from Mouse Skeletal Muscle.Bio-protocol · 2022Article
- Monocyte/Macrophage Heterogeneity during Skin Wound Healing in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Single-Cell Metabolic Profiling of Macrophages Using 3D OrbiSIMS: Correlations with Phenotype.Analytical chemistry · 2022Article
- Robust temporal map of human in vitro myelopoiesis using single-cell genomics.Nature communications · 2022Article
- Synovial inflammation in osteoarthritis progression.Nature reviews. Rheumatology · 2022Review
- Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance.Annual review of immunology · 2022Review
- The Human Monocyte-A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation.International journal of molecular sciences · 2022Article
- Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems.International journal of molecular sciences · 2022Article
- P2Y6 receptor-mediated signaling amplifies TLR-induced pro-inflammatory responses in microglia.Frontiers in immunology · 2022Article
- The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections.Frontiers in aging · 2022Review
- Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins.Molecules (Basel, Switzerland) · 2021Review
- Transcriptional repression shapes the identity and function of tissue macrophages.FEBS open bio · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Macrophages are key players in immunity and tissue homeostasis but can also contribute to a diverse range of human diseases, including cardiovascular diseases. Enhancers, cis-acting DNA elements regulating gene activity, have been shown to be crucial for control of macrophage development and function. The selection and activities of macrophage-specific enhancers are regulated by the combined actions of lineage determining transcription factors (LDTFs) and signal dependent transcription factors (SDTFs) that are specified by developmental origin and tissue-specific signals. As a consequence, each tissue resident macrophage population adopts a distinct phenotype. In this review, we discuss recent work on how environmental factors affect the activation status of enhancers and can lead to long-lasting epigenetic changes resulting in innate immune memory. Furthermore, we discuss how non-coding genetic variation affects gene expression by altering transcription factor binding through local and domain-wide mechanisms. These findings have implications for interpretation of non-coding risk alleles that are associated with human disease and efforts to target macrophages for therapeutic purposes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.