ArticleBritish journal of pharmacology1987
The effect of platelet activating factor on pulmonary beta-adrenoceptors.
Article in British journal of pharmacology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 60 citations in OpenAlex.
- Effects of PAF on excitatory neuro-effector transmission in dog airways.British journal of pharmacology · 1992Article
- Acute hypersensitivity to aerosolized histamine induced by aerosolized ovalbumin in guinea pigs.Agents and actions · 1992Article
- Review
- PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle.British journal of pharmacology · 1990Article
- Phospholipase A2-induced pathophysiologic changes in the guinea pig lung.The American journal of pathology · 1990Article
- The role of platelet activating factor in allergic respiratory disease.British journal of clinical pharmacology · 1990Review
- Review
- Airway receptors.Postgraduate medical journal · 1989Review
- The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin.British journal of pharmacology · 1989Article
- Article
- Immediate anaphylactic bronchoconstriction induces airway hyperreactivity in anaesthetized guinea-pigs.British journal of pharmacology · 1988Article
- The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig.British journal of pharmacology · 1987Article
- Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation.British journal of pharmacology · 1987Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An intravenous infusion of platelet activating factor (Paf) in the guinea-pig elicits an increase in bronchial responsiveness to the spasmogens, histamine and bombesin. Airways obstruction induced by bombesin in Paf-treated animals is poorly reversed by isoprenaline compared to comparable airways obstruction induced by bombesin in vehicle-treated animals. Isoprenaline induced a comparable dose-related relaxation in vitro of tracheal smooth muscle isolated from Paf- and vehicle-treated animals. No change in beta-adrenoceptor numbers or binding affinity was observed in lungs removed from Paf-treated animals in comparison with those from vehicle-treated animals, or after direct incubation with Paf in vitro. The reduced bronchodilator responsiveness to isoprenaline in Paf-treated animals is not related to changes in pulmonary beta-adrenoceptor function. These results suggest that non-spasmogenic elements may contribute to airways obstruction induced in hyper-responsive animals.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.