Evidence map›Paper›PMID 30343602›Full record

ReviewIntegrative cancer therapies2018

Role of MicroRNAs Induced by Chinese Herbal Medicines Against Hepatocellular Carcinoma: A Brief Review.

Ge Guo, Juhua Zhou, Xiaogaung Yang, Jiang Feng, Yanxia Shao, Tingting Jia, Qingrong Huang, Yanmin Li, Yin Zhong, Prakash S Nagarkatti and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Network Pharmacology Approach to Reveal the Underlying Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ge Guo1 Ludong University, Yantai, Shandong, People's Republic of China.
Juhua Zhou1 Ludong University, Yantai, Shandong, People's Republic of China.
Xiaogaung Yang2 Hangzhou Hesti Biotechnology Co, Ltd, Hangzhou, Zhejiang, People's Republic of China.
Jiang Feng2 Hangzhou Hesti Biotechnology Co, Ltd, Hangzhou, Zhejiang, People's Republic of China.
Yanxia Shao1 Ludong University, Yantai, Shandong, People's Republic of China.
Tingting Jia1 Ludong University, Yantai, Shandong, People's Republic of China.
Qingrong Huang1 Ludong University, Yantai, Shandong, People's Republic of China.
Yanmin Li1 Ludong University, Yantai, Shandong, People's Republic of China.
Yin Zhong3 University of South Carolina, Columbia, SC, USA.
Prakash S Nagarkatti3 University of South Carolina, Columbia, SC, USA.
Mitzi Nagarkatti3 University of South Carolina, Columbia, SC, USA.
Ludong University · CNUniversity of South Carolina · USHangzhou DAC Biotech (China) · CN

Funding

AhR ligands in epigenetic dysregulation of T cellsR01AI123947 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI, NAGARKATTI, PRAKASH S · 2017 to 2021
$1.8M
NIAID NIH HHS R01 AI123947
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate gene expression, and consequently several important functions including early embryo development, cell cycle, programmed cell death, cell differentiation, and metabolism. While there are no effective treatments available against hepatocellular carcinoma (HCC), some Chinese herbal medicines have been shown to regulate growth, differentiation, invasion, and metastasis of HCC. Many studies have shown that Chinese herbal medicines regulate the expression of miRNAs and this may be associated with their ability to control the development of HCC. In this article, the effects of Chinese herbal medicines on the expression of miRNAs and their functions in the regulation of HCC have been reviewed and discussed. miRNAs such as miRNA-221 and miRNA-222 mediated by Chinese herbal medicines may be good biomarkers and therapeutic targets for HCC.

Indexed as

AnimalsBiomarkers, TumorCarcinoma, HepatocellularDrugs, Chinese HerbalGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMicroRNAsBiomarkers, TumorDrugs, Chinese HerbalMicroRNAsChinese herbal medicineshepatocellular carcinomamiRNAs

Identifiers

PMID30343602
PMCPMC6247546
OpenAlexW2896959864

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.