Trial reportCartilage2021
Platelet-Rich Plasma versus Corticosteroid Intra-Articular Injections for the Treatment of Trapeziometacarpal Arthritis: A Prospective Randomized Controlled Clinical Trial.
Trial report in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Randomized Controlled Trials Studying Nonoperative Treatments of Osteoarthritis Often Use Misleading and Uninformative Control Groups: A Systematic Review.Clinical orthopaedics and related research · 2025Pooled it
- Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- Regenerative Therapies for Basal Thumb Arthritis-A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Platelet-rich plasma injection for the treatment of ankle osteoarthritis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2023Pooled it
- Efficacy of corticosteroids for hand osteoarthritis - a systematic review and meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2022Pooled it
- Platelet-Rich Plasma in Plastic Surgery: A Systematic Review.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Pooled it
- Comparative Outcomes of Lumbar Platelet-Rich Plasma Injection Versus Conservative Treatment for Chronic Discogenic and/or Radicular Pain: A Retrospective Cohort Study.Biomedicines · 2026Article
- Assessing the Usability of ChatGPT Responses Compared to Other Online Information in Hand Surgery.Hand (New York, N.Y.) · 2026Article
- Platelet-rich plasma in the management of musculoskeletal disorders: a narrative review of clinical evidence and practical considerations.Frontiers in medicine · 2026Review
- Hand Osteoarthritis: Molecular Mechanisms, Randomized Controlled Trials, and the Future of Targeted Treatment.International journal of molecular sciences · 2025Review
- Safety and efficacy of platelet-rich plasma injections in basal thumb osteoarthritis; should we offer it or not?Journal of hand and microsurgery · 2025Review
- Comparison of Surgical Techniques and Joint Injections for Base of Thumb Osteoarthritis: A Systematic Review.Journal of hand surgery global online · 2025Article
- Efficacy of Intralesional Platelet-Rich Plasma in Patients With de Quervain's Tenosynovitis.Cureus · 2025Article
- Mechanistic insights into non-coding RNAs regulate autophagy in chondrocytes and their contribution to osteoarthritis.Frontiers in medicine · 2025Review
- Article
- Ultrasound guided procedures in the musculoskeletal system: a narrative review with illustrative examples.Quantitative imaging in medicine and surgery · 2024Review
- Exploring Platelet-Rich Plasma Therapy for Knee Osteoarthritis: An In-Depth Analysis.Journal of functional biomaterials · 2024Review
- Nonoperative Management of Trapeziometacarpal Joint Arthritis: A Systematic Review of the Clinical Trials.Cureus · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A prospective, randomized, blind, controlled, clinical trial of 33 patients with clinical and radiographic osteoarthritis of the TMJ (grades: I-III according to the Eaton and Littler classification) was conducted. Group A patients (16 patients) received 2 ultrasound-guided IA-PRP injections, while group B patients (17 patients) received 2 ultrasound-guided intra-articular methylprednisolone and lidocaine injections at a 2-week interval. Patients were evaluated prior to and at 3 and 12 months after the second injection using the visual analogue scale (VAS) 100/100, shortened Disabilities of the Arm, Shoulder, and Hand Questionnaire (Q-DASH), and patient's subjective satisfaction. No significant differences between the baseline clinical and demographic characteristics of the 2 groups were identified. After 12 months' follow-up, the IA-PRP treatment has yielded significantly better results in comparison with the corticosteroids, in terms of VAS score (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.