Evidence map›Paper›PMID 30343549›Full record

ArticleInternational journal of stem cells2018

Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 Expression.

Soo-Hwan Kim, Jieun Jung, Kyung Jin Cho, Jong-Ho Choi, Hyeong Seon Lee, Gi Jin Kim, Seung Gwan Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  4. Stem Cell-Based Therapies for Inflammatory Bowel Disease.International journal of molecular sciences · 2022
    Review
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Soo-Hwan KimDepartment of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Korea.
Jieun JungPlacenta Research Laboratory, Department of Biomedical Science, CHA University, Sungnam, Korea.
Kyung Jin ChoDepartment of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Korea.
Jong-Ho ChoiPlacenta Research Laboratory, Department of Biomedical Science, CHA University, Sungnam, Korea.
Hyeong Seon LeeDepartment of Biomedical Laboratory Science, Jungwon University, Goesan, Korea.
Gi Jin KimPlacenta Research Laboratory, Department of Biomedical Science, CHA University, Sungnam, Korea.
Seung Gwan LeeDepartment of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Korea.
Korea University · KRJungwon University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunomodulatory effects of mesenchymal stem cells (MSCs) are an important mediator of their therapeutic effects in stem cell therapy and regenerative medicine. The regulation mechanism of MSCs is orchestrated by several factors in both intrinsic and extrinsic events. Recent studies have shown that the dynamic expression of cytokines secreted from MSCs control T cell function and maturation by regulating the expression of FoxP3, which figures prominently in T cell differentiation. However, there is no evidence that placenta-derived mesenchymal stem cells (PD-MSCs) have strong immunomodulatory effects on T cell function and maturation via FoxP3 expression. Therefore, we compared the expression of FoxP3 in activated T cells isolated from peripheral blood and co-cultured with PD-MSCs or bone marrow-derived mesenchymal stem cells (BM-MSCs) and analyzed their effect on T cell proliferation and cytokine profiles. Additionally, we verified the immunomodulatory function of PD-MSCs by siRNA-mediated silencing of FoxP3. MSCs, including PD-MSCs and BM-MSCs, promoted differentiation of naive peripheral blood T cells into CD4+CD25+FoxP3+ regulatory T (Treg) cells. Intriguingly, the population of CD4+CD25+FoxP3+ Treg cells co-cultured with PD-MSCs was significantly expanded in comparison to those co-cultured with BM-MSCs or WI38 cells (p＜0.05, p＜0.001). Dynamic expression patterns of several cytokines, including anti- and pro-inflammatory cytokines and members of the transforming growth factor-beta (TGF-

Indexed as

CytokinesFoxP3Immunomodulatory effectsPlacenta-derived mesenchymal stem cellsRegulatory T cell

Identifiers

PMID30343549
PMCPMC6285290
OpenAlexW2898011915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.