Evidence map›Paper›PMID 30343488›Full record

ArticleCancer2019

Real-world testing and treatment patterns in chronic lymphocytic leukemia: A SEER patterns of care analysis.

Erlene K Seymour, Julie J Ruterbusch, Jennifer L Beebe-Dimmer, Charles A Schiffer

Abstract read
In one paragraph

Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erlene K SeymourDivision of Hematology/Oncology, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Julie J RuterbuschDivision of Hematology/Oncology, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Jennifer L Beebe-DimmerDivision of Hematology/Oncology, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.
Charles A SchifferDivision of Hematology/Oncology, Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
NCI NIH HHS HHSN261201300011INCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

backgroundLaboratory testing and treatments for chronic lymphocytic leukemia (CLL) have changed dramatically within the last decade. The authors evaluated changes in patterns of real-world testing and treatment over time by comparing 2 population-based cohorts.

methodsThe National Cancer Institute-sponsored Patterns of Care study was conducted among patients with CLL who were sampled from 14 Surveillance, Epidemiology, and End Results (SEER) program registries. Demographics, testing, and treatment data were abstracted from medical records within 24 months of diagnosis.

resultsA total of 1008 patients diagnosed in 2008 and 1367 patients diagnosed in 2014 were included. There was a significant increase in fluorescence in situ hybridization (FISH) testing, immunoglobulin heavy-chain variable region gene (IgV

conclusionsThere have been rapidly changing practices in the testing and treatment patterns of patients with CLL within the last decade.

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsBendamustine HydrochlorideDiagnostic Techniques and ProceduresDNA Mutational AnalysisFemaleHumansImmunoglobulin Variable RegionIn Situ Hybridization, FluorescenceLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedRituximabSEER ProgramAntineoplastic AgentsBendamustine HydrochlorideImmunoglobulin Variable RegionRituximaband End Results (SEER)chronic lymphocytic leukemia (CLL)Epidemiologypatterns of careSurveillancetestingtreatments

Identifiers

PMID30343488
PMCPMC6309467

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.