Evidence map›Paper›PMID 30343478›Full record

Observational studyMusculoskeletal surgery2018

Shoulder adhesive capsulitis and hypercholesterolemia: role of APO A1 lipoprotein polymorphism on etiology and severity.

S Gumina, V Candela, A Castagna, M Carnovale, D Passaretti, T Venditto, G Giannicola, C Villani

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Musculoskeletal surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. The effect of cellular nuclear function alteration on the pathogenesis of shoulder adhesive capsulitis: an immunohistochemical study on lamin A/C expression.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

S GuminaDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Polo Pontino (ICOT), Latina, Italy.
V CandelaDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Polo Pontino (ICOT), Latina, Italy. vittorio.candela@yahoo.it.ORCID http://orcid.org/0000-0002-6097-4136
A CastagnaDepartment of Orthopaedics and Traumatology, Humanitas Clinic, Rozzano, Milan, Italy.
M CarnovaleDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
D PassarettiDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
T VendittoDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
G GiannicolaDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
C VillaniDepartment of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
Policlinico Umberto I · ITSapienza University of Rome · ITFondazione Humanitas per la Ricerca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRelationship between shoulder adhesive capsulitis (AC) and hypercholesterolemia is known. The connecting link might be represented by the correlation between HDL and transforming growth factor beta (TGF-β): normally, HDLs stimulate TGF-β expression; the latter is employed in the development of fibrous tissue. We assess whether the presence of the Apo-A1-G75A-polymorphism, which is correlated to an enhanced HDL function, could be a risk factor for the genesis and severity of AC.

methodsPeripheral blood samples of 27 patients [7M; 20F, mean age 54.81 (41-65)] with AC and hypercholesterolemia were submitted to polymerase chain reaction in order to evaluate the Apo-A1-G75A-polymorphism. Genome database was used as control. Two categories were obtained according to AC severity: type I (active forward flexion ≥ 100°) and type II (< 100°). Data were submitted to statistics.

resultsThe prevalence of Apo-A1-G75A-polymorphism in the studied group and in the control group was 22.2% (10AG; 1AA; 16GG) and 19% (OR 1.22, IC 0.59-2.53, p > 0.05), respectively. Patients with type I and II capsulitis were 11 [flexion 148.0° (range 100°-165°)] and 16 [flexion 82.5° (range 50°-95°)], respectively. The prevalence of Apo-A1-G75A in type I was 18.1% (2AG; 9GG) and in type II was 56.3% (8GA; 1AA; 7GG), respectively (RR 1.87, IC 1.005-3.482, p < 0.05).

conclusionsApo-A1-G75A-polymorphism is not necessary for the genesis, but it is a risk factor for severity of AC. LEVEL OF EVIDENCE: III.

Indexed as

Polymorphism, GeneticAdultAgedApolipoprotein A-IBursitisFemaleHumansHypercholesterolemiaMaleMiddle AgedProspective StudiesRisk FactorsSeverity of Illness IndexAPOA1 protein, humanApolipoprotein A-IAdhesive capsulitisAdhesive capsulitis severityFrozen shoulderFrozen shoulder etiologyHypercholesterolemiaLipoproteins

Identifiers

PMID30343478
OpenAlexW2896713254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.