ReviewNeuropsychology review2018
Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.
Review in Neuropsychology review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 241 papers, 12 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
241 citing papers in PubMed, 12 syntheses or guidelines pooled it, 442 citations in OpenAlex.
- A Systematic Review of Tai Chi-based Interventions for Positive and Negative Symptoms, Cognitive Functioning, and Quality of Life in Psychosis.Community mental health journal · 2025Pooled it
- Rethinking the psychosis spectrum: A meta-analysis unveils a nonlinear discontinuity in verbal learning deficits between at-risk conditions and psychotic disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Unraveling consistently altered brain activations of language deficits in schizophrenia: evidence from ALE meta-analysis.Translational psychiatry · 2025Pooled it
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- Haloperidol versus second-generation antipsychotics on the cognitive performance of individuals with schizophrenia and related disorders: pairwise meta-analysis of randomized controlled trials.Trends in psychiatry and psychotherapy · 2025Pooled it
- Meta-analysis of Face Perception in Schizophrenia Spectrum Disorders: Evidence for Differential Impairment in Emotion Face Perception.Schizophrenia bulletin · 2024Pooled it
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Assessing social cognition in patients with schizophrenia and healthy controls using the reading the mind in the eyes test (RMET): a systematic review and meta-regression.Psychological medicine · 2024Pooled it
- Evaluating the validity of game-based assessments measuring cognitive function among children and adolescents: A systematic review and meta-analysis.Progress in brain research · 2023Pooled it
- Examining the variability of neurocognitive functioning in individuals at clinical high risk for psychosis: a meta-analysis.Translational psychiatry · 2022Pooled it
- Home practice in mindfulness-based interventions for psychosis groups: a systematic review and qualitative study.BMC psychology · 2022Pooled it
- Separating Clinical and Subclinical Depression by Big Data Informed Structural Vulnerability Index and Its impact on Cognition: ENIGMA Dot Product.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2022Pooled it
- Smartphone video games effectively improve cognitive function in middle-aged and elderly patients with chronic schizophrenia: a randomized clinical trial.Translational psychiatry · 2025Trial
- Levetiracetam as an Adjunctive Treatment for Mania: A Double-Blind, Randomized, Placebo-Controlled Trial.Neuropsychobiology · 2022Trial
- Dynamic, differentiated clinical trajectories and prediction in clinical high risk for psychosis.Molecular psychiatry · 2026Article
- Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia.Molecular psychiatry · 2026Article
- HbA1c and Cognitive Functioning Across Bipolar Disorder, Recurrent Major Depressive Disorder, and Schizophrenia: Findings from a Non-Diabetic Sample.Brain sciences · 2026Article
- Association of serum BMP2 with delayed memory impairment in first-episode, drug-naïve schizophrenia.BMC psychiatry · 2026Article
- Active Ingredients in Digital Cognitive Interventions: Integrating Dismantling Designs With Mechanistic Neuroscience.JMIR mental health · 2026Article
- Neural Responses to Reward and Psychosis Dimensions.Schizophrenia bulletin · 2026Article
181 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with disorders that include psychotic symptoms (i.e. psychotic disorders) experience broad cognitive impairments in the chronic state, indicating a dimension of abnormality associated with the experience of psychosis. These impairments negatively impact functional outcome, contributing to the disabling nature of schizophrenia, bipolar disorder, and psychotic depression. The robust and reliable nature of cognitive deficits has led researchers to explore the timing and profile of impairments, as this may elucidate different neurodevelopmental patterns in individuals who experience psychosis. Here, we review the literature on cognitive deficits across the life span of individuals with psychotic disorder and psychotic-like experiences, highlighting the dimensional nature of both psychosis and cognitive ability. We identify premorbid generalized cognitive impairment in schizophrenia that worsens throughout development, and stabilizes by the first-episode of psychosis, suggesting a neurodevelopmental course. Research in affective psychosis is less clear, with mixed evidence regarding premorbid deficits, but a fairly reliable generalized deficit at first-episode, which appears to worsen into the chronic state. In general, cognitive impairments are most severe in schizophrenia, intermediate in bipolar disorder, and the least severe in psychotic depression. In all groups, cognitive deficits are associated with poorer functional outcome. Finally, while the generalized deficit is the clearest and most reliable signal, data suggests specific deficits in verbal memory across all groups, specific processing speed impairments in schizophrenia and executive functioning impairments in bipolar disorder. Cognitive deficits are a core feature of psychotic disorders that provide a window into understanding developmental course and risk for psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.