Evidence map›Paper›PMID 30343422›Full record

ArticleAIDS and behavior2019

HIV-Related Stigma and Viral Suppression Among African-American Women: Exploring the Mediating Roles of Depression and ART Nonadherence.

Lauren Lipira, Emily C Williams, David Huh, Christopher G Kemp, Paul E Nevin, Preston Greene, Joseph M Unger, Patrick Heagerty, Audrey L French, Susan E Cohn and 5 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lauren LipiraDepartment of Health Services, University of Washington, Seattle, WA, USA. llipira@uw.edu.ORCID http://orcid.org/0000-0002-8732-6403
Emily C WilliamsDepartment of Health Services, University of Washington, Seattle, WA, USA.
David HuhSchool of Social Work, University of Washington, Seattle, WA, USA.
Christopher G KempDepartment of Global Health, University of Washington, Seattle, WA, USA.
Paul E NevinDepartment of Global Health, University of Washington, Seattle, WA, USA.
Preston GreeneVA Puget Sound Health Care System, Seattle, WA, USA.
Joseph M UngerDepartment of Health Services, University of Washington, Seattle, WA, USA.
Patrick HeagertyDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Audrey L FrenchStroger Hospital of Cook County and Ruth M. Rothstein CORE Center, Chicago, IL, USA.
Susan E CohnDivision of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Janet M TuranDepartment of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
Michael J MugaveroDivision of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA.
Jane M SimoniDepartment of Psychology, University of Washington, Seattle, WA, USA.
Michele P AndrasikDepartment of Global Health, University of Washington, Seattle, WA, USA.
Deepa RaoDepartment of Global Health, University of Washington, Seattle, WA, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
University of Washington Health Services Research Training ProgramT32HS013853 · AHRQ · UNIVERSITY OF WASHINGTON · PI WEINER, BRYAN J., WILLIAMS, EMILY CATERINA · 2003 to 2024
$6.9M
Reducing HIV Stigma to Improve Health Outcomes for African-American WomenR01MH098675 · NIMH · UNIVERSITY OF WASHINGTON · PI RAO, DEEPA · 2012 to 2016
$2.6M
Agency for Healthcare Research and Quality T32 HS013853-13AHRQ HHS T32 HS013853Health Services Research and Development CDA 12-276NIAID NIH HHS P30 AI027757NIMH NIH HHS R01 MH098675NIMH NIH HHS R01-MH98675
6 · The paper itself

Abstract

We used baseline data from a sample of African-American women living with HIV who were recruited to participate in a stigma-reduction intervention in Chicago and Birmingham (2013-2015) to (1) evaluate the relationship between HIV-related stigma and viral suppression, and (2) assess the role of depression and nonadherence to antiretroviral therapy (ART) as mediators. Data from women were included in this secondary analysis if they were on ART, had viral load data collected within 8-weeks of study entry and had complete covariate data. We used logistic regression to estimate the total effect of HIV-related stigma (14-item Stigma Scale for Chronic Illness) on viral suppression (< 200 copies/mL), and serial mediation analysis to estimate indirect effects mediated by depressive symptoms (8-item Patient Health Questionnaire) and ART nonadherence (number of days with missed doses). Among 100 women who met study inclusion criteria, 95% reported some level of HIV-related stigma. In adjusted models, higher levels of HIV-related stigma were associated with lower odds of being virally suppressed (AOR = 0.93, 95% CI = 0.89-0.98). In mediation analysis, indirect effects through depression and ART nonadherence were not significant. Findings suggest that HIV-related stigma is common among African-American women living with HIV, and those who experience higher levels of stigma are less likely to be virally suppressed. However, the mechanisms remain unclear.

Indexed as

Social StigmaAdultAlabamaAnti-Retroviral AgentsBlack or African AmericanChicagoCross-Sectional StudiesDepressionDepressive DisorderFemaleHIVHIV InfectionsHumansMedication AdherenceMiddle AgedViral LoadAnti-Retroviral AgentsAfrican-American womenART adherenceDepressionHIV stigmaViral suppression

Identifiers

PMID30343422
PMCPMC6815932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.