ArticleMolecular biology reports2018
Expression patterns of candidate genes reflecting the growth performance of goats subjected to heat stress.
Article in Molecular biology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Single Nucleotide Polymorphisms of Growth Hormone and Insulin-Like Growth Factor-1 Genes and Their Association With Growth Traits of Goats: A Systematic Review.Veterinary medicine and science · 2026Pooled it
- Review
- Impacts of heat stress on growth performance and its mitigation in small ruminants.Animal frontiers : the review magazine of animal agriculture · 2025Article
- Effects of Herbal Supplementation on Growth Performance of Kenguri Sheep Exposed to Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Effects of Heat Stress on Goat Production and Mitigating Strategies: A Review.Animals : an open access journal from MDPI · 2024Review
- Heat Stress and Goat Welfare: Adaptation and Production Considerations.Animals : an open access journal from MDPI · 2021Review
- Emerging Genetic Tools to Investigate Molecular Pathways Related to Heat Stress in Chickens: A Review.Animals : an open access journal from MDPI · 2020Review
- Effect of heat stress on the quantitative expression patterns of different cytokine genes in Malabari goats.International journal of biometeorology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study is an attempt to elucidate the molecular mechanisms governing growth performance during heat stress in goats. The primary objective of the study was to establish the influence of heat stress on the expression patterns of different growth related genes in Malabari goats. The study was conducted for a period of 45 days in 12 Malabari goats randomly allocated into two groups: MC (n = 6; Malabari control) and MHS (n = 6; Malabari heat stress). At the end of study period, all 12 animals were slaughtered and their liver tissues were collected for gene expression and histopathological studies. The temperature-humidity-index (THI) inside the shed (74.9) proved that the animals were not stressed while in the outside environment (86.5) the animals were extremely distressed. The hepatic growth hormone (GH), growth hormone receptor (GHR), insulin-like growth factor-1 (IGF-1), leptin (LEP) and leptin receptor (LEPR) gene expression patterns were significantly (P < 0.05) lower in heat stress group as compared to the control group animals. In addition, negative correlation (P < 0.05) was also established between THI and all the growth related gene expression in the study. The hepatic histopathological section showed more fatty and degenerative changes (P < 0.05) in hepatocytes in MHS group as compared to MC group. The study offers the first thorough insight into the expression patterns of different growth related genes during heat stress exposure in goats. Further, the study established GH, GHR, IGF-1, LEP, LEPR genes to be the ideal markers to reflect growth potential in Malabari goats.
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