Evidence map›Paper›PMID 30343368›Full record

ArticleJournal of molecular neuroscience : MN2018

Altered S100 Calcium-Binding Protein B and Matrix Metallopeptidase 9 as Biomarkers of Mesial Temporal Lobe Epilepsy with Hippocampus Sclerosis.

Nagwa A Meguid, Hatem Samir, Geir Bjørklund, Mona Anwar, Adel Hashish, Farouk Koura, Salvatore Chirumbolo, Saher Hashem, Mona A El-Bana, Hebatalla S Hashem

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Blood biomarkers in epilepsy.Acta neurologica Scandinavica · 2022
    Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Nagwa A MeguidResearch on Children with Special Needs Department, National Research Centre, Giza, Egypt.
Hatem SamirNeurology Department, Cairo University, Cairo, Egypt.
Geir BjørklundCouncil for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.ORCID http://orcid.org/0000-0003-2632-3935
Mona AnwarResearch on Children with Special Needs Department, National Research Centre, Giza, Egypt.
Adel HashishResearch on Children with Special Needs Department, National Research Centre, Giza, Egypt.
Farouk KouraNeurology Department, Cairo University, Cairo, Egypt.
Salvatore ChirumboloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Saher HashemNeurology Department, Cairo University, Cairo, Egypt.
Mona A El-BanaMedical Biochemistry Department, National Research Centre, Giza, Egypt.
Hebatalla S HashemResearch on Children with Special Needs Department, National Research Centre, Giza, Egypt.
National Research Centre · EGCairo University · EGThe Research Council of Norway · NOUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis (HS) is the most common form of partial epilepsy. The aim of the present study is to highlight possible and suitable biomarkers that can help in the diagnosis and prognosis of this intractable form of epilepsy. The study was carried out on 30 epileptic patients of both sexes with complex partial seizures, having an age ranging from 4 to 30 years and were selected from the outpatient epilepsy clinic at the Kasr El-Aini Hospital in Cairo, Egypt. Thirty healthy children and young adults, age- and sex-matched to the patients, were included in the study as controls. Patients with epilepsy and healthy controls were subjected to a set of laboratory analyses including S100 calcium-binding protein B (S100B), matrix metallopeptidase 9 (MMP9), C-reactive protein (CRP), and prolactin (PRL), in addition to neurophysiological, radiological, and psychometric assessments, on the basis of the recent evidence of the field. The results of this study showed a marked increase in the investigated biomarkers in patients with epilepsy compared to controls. The performance of the epileptic patients in psychometric assessments was below the average threshold, with the MRI analysis showing specific findings of mesial temporal sclerosis (MTS) and EEG showing anterior temporal spikes. A significant negative correlation was found between MMP9 and psychometric test. On the other hand, a significant positive correlation was observed between seizure severity and the indicated biomarker. The present study suggests that S100B and MMP9 could be used as biomarkers for neuronal injury and helps in the prognosis of MTLE.

Indexed as

AdolescentAdultBiomarkersCase-Control StudiesChildChild, PreschoolC-Reactive ProteinEpilepsy, Temporal LobeFemaleHippocampusHumansMaleMatrix Metalloproteinase 9ProlactinS100 Calcium Binding Protein beta SubunitSclerosisBiomarkersC-Reactive ProteinMatrix Metalloproteinase 9MMP9 protein, humanProlactinS100B protein, humanS100 Calcium Binding Protein beta SubunitHippocampal sclerosisMatrix metallopeptidase 9Mesial temporal lobe epilepsyProlactinS100 calcium-binding protein B

Identifiers

PMID30343368
OpenAlexW2896453863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.