ArticleBrain structure & function2019
Aldosterone-sensitive HSD2 neurons in mice.
Article in Brain structure & function, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 67 citations in OpenAlex.
- Molecular Ontology Predicts Output Connections From the Nucleus of the Solitary Tract.The Journal of comparative neurology · 2026Article
- Rapidly decreasing phasic dopamine responses precede a hedonic switch during satiation of sodium appetite.bioRxiv : the preprint server for biology · 2026Article
- Science with Seymour Levine: on glucocorticoid action from birth to senescence.Neurobiology of stress · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026Article
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
- What's the occasion? Phasic dopamine signaling and interoception.Current opinion in neurobiology · 2025Review
- Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Specific Control of Micturition.Research square · 2025Article
- Aldosterone-induced salt appetite requires HSD2 neurons.JCI insight · 2024Article
- Molecular Ontology of the Nucleus of Solitary Tract.The Journal of comparative neurology · 2024Article
- Control of sodium appetite by hindbrain aldosterone-sensitive neurons.Molecular and cellular endocrinology · 2024Review
- Efferent projections of Nps-expressing neurons in the parabrachial region.The Journal of comparative neurology · 2024Article
- Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss.American journal of physiology. Endocrinology and metabolism · 2024Review
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Treatment withNutrients · 2024Article
- Coping with the multifaceted and multifunctional role of cortisol in the brain.Neuroscience applied · 2024Review
- The cortisol switch between vulnerability and resilience.Molecular psychiatry · 2024Review
- Aldosterone in the brain and cognition: knowns and unknowns.Frontiers in endocrinology · 2024Review
- Whole-brain inputs and outputs of Phox2b and GABAergic neurons in the nucleus tractus solitarii.Frontiers in neuroscience · 2024Article
- Feeding signals inhibit fluid-satiation signals in the mouse lateral parabrachial nucleus to increase intake of highly palatable, caloric solutions.Journal of neurochemistry · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sodium deficiency elevates aldosterone, which in addition to epithelial tissues acts on the brain to promote dysphoric symptoms and salt intake. Aldosterone boosts the activity of neurons that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a hallmark of aldosterone-sensitive cells. To better characterize these neurons, we combine immunolabeling and in situ hybridization with fate mapping and Cre-conditional axon tracing in mice. Many cells throughout the brain have a developmental history of Hsd11b2 expression, but in the adult brain one small brainstem region with a leaky blood-brain barrier contains HSD2 neurons. These neurons express Hsd11b2, Nr3c2 (mineralocorticoid receptor), Agtr1a (angiotensin receptor), Slc17a6 (vesicular glutamate transporter 2), Phox2b, and Nxph4; many also express Cartpt or Lmx1b. No HSD2 neurons express cholinergic, monoaminergic, or several other neuropeptidergic markers. Their axons project to the parabrachial complex (PB), where they intermingle with AgRP-immunoreactive axons to form dense terminal fields overlapping FoxP2 neurons in the central lateral subnucleus (PBcL) and pre-locus coeruleus (pLC). Their axons also extend to the forebrain, intermingling with AgRP- and CGRP-immunoreactive axons to form dense terminals surrounding GABAergic neurons in the ventrolateral bed nucleus of the stria terminalis (BSTvL). Sparse axons target the periaqueductal gray, ventral tegmental area, lateral hypothalamic area, paraventricular hypothalamic nucleus, and central nucleus of the amygdala. Dual retrograde tracing revealed that largely separate HSD2 neurons project to pLC/PB or BSTvL. This projection pattern raises the possibility that a subset of HSD2 neurons promotes the dysphoric, anorexic, and anhedonic symptoms of hyperaldosteronism via AgRP-inhibited relay neurons in PB.
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