SynthesisArchives of orthopaedic and trauma surgery2019
Insights into treatment and outcome of fracture-related infection: a systematic literature review.
Synthesis in Archives of orthopaedic and trauma surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05467644 (Treatment of Fracture Related Infection in Latin America. International Multicenter Study), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Fracture Related Infection in Latin America. International Multicenter Study
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Role of Negative-Pressure Wound Therapy in Patients with Fracture-Related Infection: A Systematic Review and Critical Appraisal.BioMed research international · 2021Pooled it
- Gentamicin-Coated Tibia Nail in Fractures and Nonunion to Reduce Fracture-Related Infections: A Systematic Review.Molecules (Basel, Switzerland) · 2020Pooled it
- Increased Risk of Infections and Mortality Following Fractures in Multiple Myeloma: A Nationwide Population-Based Retrospective Cohort Study.Health science reports · 2026Article
- Peri-implant soft tissue colonization after osteosynthesis in asymptomatic patients: a prospective study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Osteomyelitis.Nature reviews. Disease primers · 2026Review
- Review
- Clinical efficacy of Masquelet technique in the treatment of tibial and fibular bone defects caused by severe gunshot wounds.Frontiers in medicine · 2026Article
- Twenty common errors in the prevention, diagnosis, and treatment of fracture-related infection (FRI).Journal of bone and joint infection · 2026Review
- Sonication fluid cultures enhance pathogen identification in fracture-related-infection (FRI).Journal of bone and joint infection · 2026Article
- Diagnosis and management of fracture-related infections in a low-income country: a prospective study comparing current practice to international consensus guidelines.Journal of bone and joint infection · 2026Article
- Investigating long-term quality of life and depressive symptoms following fracture-related infection: a systematic review with meta-analysis of heterogeneous evidence.Journal of bone and joint infection · 2026Review
- Fracture-Related Infections: Current Status and Perspectives from the International Society of Antimicrobial Chemotherapy.Antibiotics (Basel, Switzerland) · 2025Review
- Implementation of nanographene oxide combined with mineral trioxide aggregate and hydroxyapatite biopolymer in regeneration of critical-sized bone defect in rats.Scientific reports · 2025Article
- Identifying risk factors for systemic complications following fracture-related infection.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Analysis of risk factors, pathogenic bacteria characteristics, and drug resistance of postoperative surgical site infection in adults with limb fractures.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Tibial shaft fractures: A bibliometric analysis of the top 50 most cited publications.Journal of orthopaedics · 2025Article
- Bisphosphonate-Conjugated Sitafloxacin for Treatment ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Lag analysis of the effect of air pollution on orthopedic postoperative infection in Hebei Province and Xinjiang Uygur Autonomous Region.Scientific reports · 2025Article
- Surgical and microbiological characteristics that influence the probability of reoperation to promote bone healing after fracture-related infection diagnosis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Effective detection of staphylococcal infections in human bone tissue using combined raman microscopy and micro-computed tomography.Frontiers in bioengineering and biotechnology · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStandardized guidelines for treatment of fracture-related infection (FRI) are lacking. Worldwide many treatment protocols are used with variable success rates. Awareness on the need of standardized, evidence-based guidelines has increased in recent years. This systematic literature review gives an overview of available diagnostic criteria, classifications, treatment protocols, and related outcome measurements for surgically treated FRI patients.
methodsA comprehensive search was performed in all scientific literature since 1990. Studies in English that described surgical patient series for treatment of FRI were included. Data were collected on diagnostic criteria for FRI, classifications used, surgical treatments, follow-up protocols, and overall outcome. A systematic review was performed according to the PRISMA statement. Proportions and weighted means were calculated.
resultsThe search yielded 2051 studies. Ninety-three studies were suitable for inclusion, describing 3701 patients (3711 fractures) with complex FRI. The population consisted predominantly of male patients (77%), with the tibia being the most commonly affected bone (64%), and a mean of three previous operations per patient. Forty-three (46%) studies described FRI at one specific location. Only one study (1%) used a standardized definition for infection. A total of nine different classifications were used to guide treatment protocols, of which Cierny and Mader was used most often (36%). Eighteen (19%) studies used a one-stage, 50 (54%) a two-stage, and seven (8%) a three-stage surgical treatment protocol. Ten studies (11%) used mixed protocols. Antibiotic protocols varied widely between studies. A multidisciplinary approach was mentioned in only 12 (13%) studies.
conclusionsThis extensive literature review shows a lack of standardized guidelines with respect to diagnosis and treatment of FRI, which mimics the situation for prosthetic joint infection identified many years ago. Internationally accepted guidelines are urgently required to improve the quality of care for patients suffering from this significant complication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.