ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Abnormal Prefrontal Development in Pediatric Posttraumatic Stress Disorder: A Longitudinal Structural and Functional Magnetic Resonance Imaging Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.Neuroscience and biobehavioral reviews · 2022Pooled it
- Neuroprogression in post-traumatic stress disorder: a systematic review.Trends in psychiatry and psychotherapyPooled it
- Orbitofrontal cortex-hippocampus potentiation mediates relief for depression: A randomized double-blind trial and TMS-EEG study.Cell reports. Medicine · 2023Trial
- Traumatic stress recruits an excitatory orbitofrontal-amygdala pathway to drive maladaptive aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Differential adolescent neurodevelopment of emotion processing across internalizing psychopathology and childhood adversity.Developmental cognitive neuroscience · 2026Article
- Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress.Biological psychiatry global open science · 2026Article
- Preventing traumatic stress-induced behavioral abnormalities in rats with blue light phototherapy.Translational psychiatry · 2026Article
- Magnetic Resonance Imaging Textural Changes Are More Sensitive Than Volumetric Changes in the Amygdala of Cocaine Use Disorder Patients.NMR in biomedicine · 2026Article
- The Convergence of Autism Spectrum Disorder and Intimate Partner Violence: Implications for Clinical Practice.Journal of child & adolescent trauma · 2025Article
- Plasticity of human resilience mechanisms.Science advances · 2025Article
- Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females.Scientific reports · 2025Article
- The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post-Traumatic Stress Disorder.Brain and behavior · 2025Review
- Increased functional connectivity of amygdalar-frontal pathways in patients with alcohol use disorder and childhood trauma.Neuroimage. Reports · 2024Article
- Long-term effects of childhood single-parent family structure on brain connectivity and psychological well-being.Brain imaging and behavior · 2024Article
- Trauma and the default mode network: review and exploratory study.Frontiers in behavioral neuroscience · 2024Article
- Differential Cortical Volume and Surface Morphometry in Youth With Chronic Health Conditions.Biological research for nursing · 2024Article
- Through a Developmental Lens: Emerging Insights to Understand and Treat Pediatric PTSD.The American journal of psychiatry · 2023Review
- Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review.Journal of personalized medicine · 2023Review
- Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence.Environment international · 2023Article
- Mechanisms of Maternal Diet-Induced Obesity Affecting the Offspring Brain and Development of Affective Disorders.Metabolites · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrior studies of pediatric posttraumatic stress disorder (PTSD) have reported cross-sectional and age-related structural and functional brain abnormalities in networks associated with cognitive, affective, and self-referential processing. However, no reported studies have comprehensively examined longitudinal gray matter development and its intrinsic functional correlates in pediatric PTSD.
methodsTwenty-seven youths with PTSD and 21 nontraumatized typically developing (TD) youths were assessed at baseline and 1-year follow-up. At each visit, youths underwent structural magnetic resonance imaging and resting-state functional magnetic resonance imaging. Regions with volumetric abnormalities in whole-brain structural analyses were identified and used as seeds in exploratory intrinsic connectivity analyses.
resultsYouths with PTSD exhibited sustained reductions in gray matter volume (GMV) in right ventromedial prefrontal cortex (PFC) and bilateral ventrolateral PFC. Group-by-time analyses revealed aberrant longitudinal development in dorsolateral PFC, where typically developing youths exhibited normative decreases in GMV between baseline and follow-up, and youths with PTSD showed increases in GMV. Using these regions as seeds, patients with PTSD exhibited atypical longitudinal decreases in intrinsic PFC-amygdala and PFC-hippocampus connectivity, in contrast to increases in typically developing youths. Specifically, youths with PTSD showed decreasing ventromedial PFC-amygdala connectivity as well as decreasing ventrolateral PFC-hippocampus connectivity over time. Notably, volumetric abnormalities in ventromedial PFC and ventrolateral PFC were predictive of symptom severity.
conclusionsThese findings represent novel longitudinal volumetric and connectivity changes in pediatric PTSD. Atypical prefrontal GMV and prefrontal-amygdala/hippocampus development may underlie persistence of PTSD in youths and could serve as future therapeutic targets.
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