Observational studyJACC. Cardiovascular imaging2020
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients.
Observational study in JACC. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374564 (Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Association of rheumatoid arthritis with major adverse cardiovascular events despite normal myocardial perfusion imaging.American journal of preventive cardiology · 2026Article
- Coronary microvascular dysfunction in systemic sclerosis: insights from PET-derived myocardial flow reserve.Rheumatology (Oxford, England) · 2026Article
- Multimodal Cardiac Imaging of Immune-Mediated Complications Post Heart Transplantation: A Contemporary Review.Journal of the American Heart Association · 2026Review
- Contemporary Antibody-Mediated Rejection in Heart Transplantation: JACC: Heart Failure Position Statement.JACC. Heart failure · 2025Review
- Can the grading of mild cardiac allograft vasculopathy be further refined? An angiographic and physiologic assessment of heart transplant recipients with ISHLT CAV 1.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- PET/CT with Myocardial Blood Flow Assessment Is Prognostic of Cardiac Allograft Vasculopathy Progression and Clinical Outcomes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Quantitative flow ratio computed from invasive coronary angiography as a predictor for cardiac allograft vasculopathy after cardiac transplant.The international journal of cardiovascular imaging · 2024Article
- Future of Radionuclide Myocardial Perfusion Imaging: Transitioning from SPECT to PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Prognostic value of myocardial flow reserve derived by quantitative SPECT for patients with intermediate coronary stenoses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The Role of Cardiac PET in Diagnosis and Prognosis of Ischemic Heart Disease: Optimal Modality Across Different Patient Populations.Current atherosclerosis reports · 2023Review
- Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Noninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events.Journal of the American College of Cardiology · 2022Article
- Prognostic value of myocardial flow reserve obtained by 82-rubidium positron emission tomography in long-term follow-up after heart transplantation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The role of non-invasive imaging modalities in cardiac allograft vasculopathy: an updated focus on current evidences.Heart failure reviews · 2022Review
- Prognostic utility of longitudinal quantification of PET myocardial blood flow early post heart transplantation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Defining the role for PET myocardial blood flow early post cardiac transplant.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- In Vivo Imaging of Rat Vascularity with FDG-Labeled Erythrocytes.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Coronary Flow Evaluation in Heart Transplant Patients Compared to Healthy Controls Documents the Superiority of Coronary Flow Velocity Reserve Companion as Diagnostic and Prognostic Tool.Frontiers in cardiovascular medicine · 2022Article
- Evaluation of cardiac allograft vasculopathy by positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesThis study aimed to evaluate the long-term prognostic value of serial assessment of coronary flow reserve (CFR) by rubidium Rb 82 (
backgroundCardiac allograft vasculopathy is a major determinant of late mortality in HT recipients. The long-term prognostic value of serial CFR quantification by PET imaging in HT patients is unknown.
methodsA total of 89 patients with history of HT (71% men, 7.0 ± 5.7 years post-HT, age 57 ± 11 years) scheduled for dynamic rest and stress (dipyridamole)
resultsForty deaths occurred during the median follow-up time of 8.6 years. Low CFR at PET-1 was associated with a 2.77-fold increase in all-cause mortality (95% confidence interval [CI]: 1.34 to 5.74; p = 0.004). CFR decreased over time in patients with follow-up imaging (PET-1: 2.11 ± 0.74 vs. PET-2: 1.81 ± 0.61; p = 0.003). Twenty-five patients were reclassified based on PET-1 and PET-2 (high to low CFR: n = 18, low to high CFR: n = 7). Overall survival was similar in patients reclassified from high to low as patients with low to low CFR, whereas patients reclassified from low to high had similar survival as patients with high to high CFR. In multivariate Cox regression of patients with PET-2, higher baseline CFR (hazard ratio [HR] for a 0.73 unit (one SD) increase: 0.36, 95% CI: 0.16 to 0.82) and reduction in CFR from PET-1 to PET-2 (HR for a 0.79 unit (one SD) decrease: 1.50 to 7.84) were independent predictors of all-cause mortality.
conclusionsSerial assessment of CFR by
Indexed as
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