Evidence map›Paper›PMID 30343071›Full record

ArticleJACC. Cardiovascular imaging2019

Right Atrial Phasic Function in Heart Failure With Preserved and Reduced Ejection Fraction.

Snigdha Jain, Daniel Kuriakose, Ilaina Edelstein, Bilal Ansari, Garrett Oldland, Swetha Gaddam, Khuzaima Javaid, Pritika Manaktala, Jonathan Lee, Rachana Miller and 2 more

Open access · greenAbstract readComparative StudyVideo-Audio Media
In one paragraph

Article in JACC. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Right Heart Diastology, Where Are We Now?Circulation research · 2026
    Review
  4. Article
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  6. Association of Airflow Obstruction and Left Atrial Conduit Strain in Patients with Known or Suspected Coronary Artery Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Snigdha JainDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas.
Daniel KuriakoseDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Ilaina EdelsteinDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Bilal AnsariDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Garrett OldlandDepartments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia.
Swetha GaddamDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Departments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia.
Khuzaima JavaidDepartments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia.
Pritika ManaktalaDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Jonathan LeeDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Rachana MillerDepartments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Scott R AkersDepartments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia.
Julio A ChirinosDepartment of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Departments of Internal Medicine and Radiology, Corporal Michael J. Crescenz VAMC, Philadelphia, Philadelphia; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: Julio.chirinos@uphs.upenn.edu.
Hospital of the University of Pennsylvania · USPhiladelphia VA Medical Center · USSouthwestern Medical Center · US

Funding

Efficacy of Potassium Nitrate in Heart Failure with Preserved Ejection FractionR01HL121510 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2019
$3.1M
Targeting Central Pulsatile Hemodynamics in Chronic Kidney DiseaseR56HL124073 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2015 to 2015
$594k
Targeting Wave Reflections in Heart Failure with Preserved Ejection FractionR21AG043802 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2013 to 2014
$440k
NHLBI NIH HHS R01 HL121510NHLBI NIH HHS R56 HL124073NIA NIH HHS R21 AG043802
6 · The paper itself

Abstract

objectivesThis study researched right atrial (RA) deformation indexes and their association with all-cause mortality among subjects with or without heart failure (HF).

backgroundAlthough left atrial dysfunction is well described in HF, patterns of RA dysfunction and their prognostic implications are unclear. Cardiac magnetic resonance (CMR) imaging can provide excellent visualization of the RA. We used CMR to characterize RA phasic function in HF and to assess its prognostic implications.

methodsThis study prospectively examined 608 adults without HF (n = 407), as well as adults with HF with a reduced ejection fraction (HFrEF) (n = 105) or with HF with a preserved ejection fraction (HFpEF) (n = 96). Phasic RA function was measured via volume measurements and feature-tracking methods to derive longitudinal strain. All-cause death was ascertained over a median follow-up of 38.9 months. Standardized hazard ratios (HRs) were computed via Cox regression.

resultsMeasures of RA phasic function were more prominently impaired in subjects with HFrEF than those in subjects with HFpEF. In analyses that adjusted for demographic factors, HF status, left ventricular ejection fraction, right ventricular end-diastolic volume index, and right ventricular ejection fraction, RA reservoir strain (HR: 0.66; 95% confidence interval [CI]: 0.47 to 0.92; p = 0.0154), RA expansion index (HR: 0.53; 95% CI: 0.31 to 0.91; p = 0.0116), RA conduit strain (HR: 0.58; 95% CI: 0.40 to 0.84; p = 0.0039), and RA conduit strain rate (HR: 1.51; 95% CI: 1.02 to 2.220; p = 0.0373) independently predicted all-cause mortality. In contrast, RA booster pump function and RA volume index did not independently predict the risk of death.

conclusionsPhasic RA function is predictive of the risk of all-cause death in a diverse group of subjects with and without HF. RA conduit and reservoir function are independent predictors of mortality.

Indexed as

Atrial Function, RightMagnetic Resonance Imaging, CineStroke VolumeVentricular Function, LeftAgedCase-Control StudiesCause of DeathFemaleHeart FailureHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRisk Assessmentfeature trackinglongitudinal strainmagnetic resonance imagingright atrium

Identifiers

PMID30343071
PMCPMC6461533
OpenAlexW2896939361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.