Evidence map›Paper›PMID 30343070›Full record

Observational studyJACC. Cardiovascular imaging2019

Mechanisms of Myocardial Infarction in Patients With Nonobstructive Coronary Artery Disease: Results From the Optical Coherence Tomography Study.

Maksymilian P Opolski, Mateusz Spiewak, Magdalena Marczak, Artur Debski, Paul Knaapen, Stefan P Schumacher, Adam D Staruch, Kajetan Grodecki, Zbigniew Chmielak, Hubert Lazarczyk and 8 more

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in JACC. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02783963 (Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02783963 nacompletednot on this map

Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease: OCT and CMR Study (SOFT-MI)

TypeinterventionalSponsorNational Institute of Cardiology, Warsaw, PolandRan2015 to 2017Enrolled38ConditionsMyocardial InfarctionArmsOCT and CMR imaging
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  8. Optical Coherence Tomography in Acute Coronary Syndromes.Reviews in cardiovascular medicine · 2025
    Review
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  11. Myocardial Infarction with Nonobstructive Coronary Artery Disease-Definition, Etiopathogenesis, Diagnosis, and Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Maksymilian P OpolskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland. Electronic address: opolski.mp@gmail.com.
Mateusz SpiewakMagnetic Resonance Unit, Department of Radiology, Institute of Cardiology, Warsaw, Poland.
Magdalena MarczakMagnetic Resonance Unit, Department of Radiology, Institute of Cardiology, Warsaw, Poland.
Artur DebskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Paul KnaapenDepartment of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
Stefan P SchumacherDepartment of Cardiology, VU University Medical Center, Amsterdam, the Netherlands.
Adam D StaruchDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Kajetan GrodeckiFirst Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
Zbigniew ChmielakDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Hubert LazarczykDepartment of Information Technology, Institute of Cardiology, Warsaw, Poland.
Krzysztof KukulaDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Pawel TyczynskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Jerzy PregowskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Maciej DabrowskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Jacek KadzielaDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Elzbieta FlorczakDepartment of Hypertension, Institute of Cardiology, Warsaw, Poland.
Anna SkrobiszDepartment of Intensive Cardiac Therapy, Institute of Cardiology, Warsaw, Poland.
Adam WitkowskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Institute of Cardiology · PLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study sought to assess the presence and morphological features of coronary plaques on optical coherence tomography (OCT) as the causes of myocardial infarction with nonobstructive coronary arteries (MINOCA).

backgroundAlthough coronary atherosclerosis has been postulated as a potential mechanism of MINOCA, the interaction between disrupted coronary plaques and myocardial injury remains unknown.

methodsIn a prospective study, consecutive patients with MI but without significant coronary stenosis (≥50%) at angiography underwent OCT and cardiac magnetic resonance (CMR) with late gadolinium-enhancement (LGE). The infarct-related artery (IRA) was identified by localization of ischemic-type LGE.

resultsThirty-eight MINOCA patients (mean age 62 ± 13 years, 55% female, 39% with ST-segment elevation) were enrolled. Maximal diameter stenosis was 35% by angiography, and 5 patients (13%) had normal angiogram results. Plaque disruption and coronary thrombus were observed in 9 patients (24%) and 7 patients (18%), respectively. Sixteen of 31 patients (52%) undergoing CMR showed LGE. Ischemic-type LGE was present in 7 patients (23%) and was more common in patients with than without plaque disruption (50% vs. 13%, respectively; p = 0.053) and coronary thrombus (67% vs. 12%, respectively; p = 0.014). In the per-lesion analysis, the IRA showed significantly more plaque disruption (40% vs. 6%; p = 0.02), thrombus (50% vs. 4%; p = 0.014), and thin-cap fibroatheroma (70% vs. 30%; p = 0.03) than the non-IRA.

conclusionsPlaque disruption and thrombus are not uncommon in MI without obstructive coronary stenoses at angiography and may be associated with the presence and location of ischemic-type myocardial injury on CMR. OCT may be valuable in identifying atherosclerotic etiology in individuals with MINOCA. (Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease [SOFT-MI]; NCT02783963).

Indexed as

Plaque, AtheroscleroticTomography, Optical CoherenceAdultAgedCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisCoronary VesselsFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsProspective Studiescardiac magnetic resonancecoronary artery diseasemyocardial infarction with nonobstructive coronary arteriesoptical coherence tomography

Identifiers

PMID30343070
OpenAlexW2896629785

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.