ArticleAnnals of clinical microbiology and antimicrobials2018
Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains.
Article in Annals of clinical microbiology and antimicrobials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
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- Toxic Shock Syndrome Toxin-1 (TSST-1) inToxins · 2025Review
- Photo-curing hyaluronic acid-Janus antibacterial packs as OMaterials today. Bio · 2025Article
- Recent development and fighting strategies for lincosamide antibiotic resistance.Clinical microbiology reviews · 2024Review
- Inducible clindamycin resistance among clinical Gram-positive cocci in a tertiary hospital in Niger Republic.Access microbiology · 2024Article
- Immunomodulatory Effects of Macrolides Considering Evidence from Human and Veterinary Medicine.Microorganisms · 2022Review
- Antibacterial Activity ofMolecules (Basel, Switzerland) · 2022Article
- Diagnostic MALDI-TOF MS can differentiate between high and low toxicMicrobiology (Reading, England) · 2022Article
- Genetic Diversity and Virulence Profile of Methicillin and Inducible Clindamycin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Rapid Antibiotic Resistance Serial Prediction inFrontiers in microbiology · 2022Article
- Clinically Important Toxins in Bacterial Infection: Utility of Laboratory Detection.Clinical microbiology newsletter · 2020Article
- Article
- Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms.Therapeutic advances in chronic disease · 2019Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clindamycin is a protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus. Recent guidelines recommend the use of clindamycin for the treatment of toxin-mediated infections. Clindamycin modulates virulence expression at sub-inhibitory concentrations (sub-MICs) in clindamycin-susceptible S. aureus strains but previous report shown that this effect was supressed for constitutive clindamycin resistant strains. However, no data are currently available on the impact of clindamycin at sub-MICs on the virulence of inducible clindamycin-resistant S. aureus strains. Here, we show that sub-MICs of clindamycin decrease Panton-Valentine leucocidin, toxic-shock-staphylococcal toxin (TSST-1) and alpha-haemolysin (Hla) expression in six inducible clindamycin-resistant isolates cultivated in vitro in CCY medium. These results suggest that the clindamycin anti-toxin effect is retained for inducible clindamycin-resistant S. aureus isolates; therefore, its usage should be considered within the treatment regimen of toxin related infections for inducible clindamycin-resistant S. aureus.
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Registered trials
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