SynthesisBMC psychiatry2018
Tooth loss as a risk factor for dementia: systematic review and meta-analysis of 21 observational studies.
Synthesis in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 9 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Dentition-Cognition Relationship in Aging Populations: A Meta-Analysis of Longitudinal Data.Journal of oral rehabilitation · 2026Pooled it
- Examining the link between tooth loss and multiple health outcomes: a comprehensive synthesis of evidence from meta-analyses.Frontiers in public health · 2026Pooled it
- Periodontitis and Tooth Loss Are Associated With Higher Risks of Cognitive Disorders: A Systematic Umbrella Meta-Analysis.Clinical and experimental dental research · 2025Pooled it
- Oral frailty indicators to target major adverse health-related outcomes in older age: a systematic review.GeroScience · 2023Pooled it
- The impact of study factors in the association of periodontal disease and cognitive disorders: systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Tooth loss and the risk of cognitive decline and dementia: A meta-analysis of cohort studies.Frontiers in neurology · 2023Pooled it
- Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies.Journal of the American Geriatrics Society · 2022Pooled it
- Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.Journal of the American Medical Directors Association · 2021Pooled it
- Influence of periodontal disease on risk of dementia: a systematic literature review and a meta-analysis.European journal of epidemiology · 2020Pooled it
- Establishment of an MRI-Based Diagnostic Approach to Identify Critical Pulpal Inflammation Zones in a Rat Caries-Derived Pulpitis Model.International endodontic journal · 2026Article
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Peri-implantitis: a systemic burden for our patients.Frontiers in dental medicine · 2026Review
- The DentoNeural Axis: A Piezo channel-mediated mechanosensory pathway linking tooth loss to cognitive decline.Aging brain · 2026Article
- Oral health and healthy aging: A multiregional review.JAR life · 2026Review
- Long-term dental care utilization trajectories as behavioral markers of cognitive aging: a 14-year national cohort study.Frontiers in public health · 2026Article
- Advances in research on dental occlusion and brain function: neuroimaging correlates and molecular mechanisms.Frontiers in neurology · 2026Review
- Different stages of Alzheimer's disease with periodontitis: clinical features and potential mechanisms involving gingipains, neuropathological biomarkers and neurological damage.Frontiers in aging neuroscience · 2026Article
- An updated systematic review and meta-analysis of tooth loss in patients with periodontitis and the risk of mild cognitive impairment.Frontiers in oral health · 2026Review
- Dental, Oral and General Health of Geriatric In-Hospital Patients Before Immediate Prosthetic Treatment: A Retrospective Cohort Study.Dentistry journal · 2025Article
- An Assessment of the Sensory Function in the Maxillofacial Region: A Dual-Case Pilot Study.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTooth loss is suggested to be associated with an increased risk of dementia in many studies. But the relationship between tooth loss and dementia is not yet fully understood. This systematic review and meta-analysis aimed to determine the relative effect of tooth loss on dementia risk.
methodsAn electronic search of PubMed, Scopus, Embase, and Web of Knowledge was conducted in March 2018 to identify relevant observational studies with the English language restriction. Studies were included if they assessed the relationship between tooth loss and risk of dementia. Study quality was detected by the modified Downs and Black scale. Odds risks (ORs) were pooled using a random-effects model in the crude model.
resultsThe literature search initially yielded 1574 articles, and 21 observational studies published between 1994 and 2017 were finally included for the analyses. The crude results with random-effects model showed that patients with multiple tooth loss had higher incidence of dementia (OR 2.62, 95% CI 1.90-3.61, P < 0.001, I
conclusionsFindings from this review evidenced that tooth loss is positively associated with an increased risk of dementia in adults. Future well-designed longitudinal researches examining the direct and indirect relationship between tooth loss and dementia risk are encouraged.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.