Evidence map›Paper›PMID 30342476›Full record

ArticleBMC infectious diseases2018

Prevalence and antibiotic susceptibility pattern of CTX-M type extended-spectrum β-lactamases among clinical isolates of gram-negative bacilli in Jimma, Ethiopia.

Ahmed Zeynudin, Michael Pritsch, Sören Schubert, Maxim Messerer, Gabriele Liegl, Michael Hoelscher, Tefara Belachew, Andreas Wieser

Abstract read
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  13. β-Lactamase and Macrolide Resistance Gene Carriage inOpen forum infectious diseases · 2024
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmed ZeynudinChair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany.
Michael PritschChair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany.ORCID http://orcid.org/0000-0001-7383-8750
Sören SchubertChair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany.
Maxim MessererPlant Genome and Systems Biology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Gabriele LieglChair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany.
Michael HoelscherCenter for International Health (CIH), University of Munich (LMU), 80802, Munich, Germany.
Tefara BelachewInstitute of Health Sciences, Jimma University, Jimma, Ethiopia.
Andreas WieserChair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer Institute, Faculty of Medicine, LMU Munich, Marchioninistr. 17, 81377, Munich, Germany. wieser@mvp.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prevalence of extended-spectrum β-lactamases (ESBLs) have been reported in clinical isolates obtained from various hospitals in Ethiopia. However, there is no data on the prevalence and antibiotic susceptibility patterns of CTX-M type ESBL produced by Gram-negative bacilli. The aim of this study was to determine the frequency and distribution of the bla

methodsA total of 224 non-duplicate and pure isolates obtained from clinically apparent infections, were included in the study. Identification of the isolates was performed by MALDI-TOF mass spectrometry. Susceptibility testing and ESBL detection was performed using VITEK® 2, according to EUCAST v4.0 guidelines. Genotypic analysis was performed using Check-MDR CT103 Microarrays.

resultsOf the total 112 (50.0%) isolates screen positive for ESBLs, 63.4% (71/112) tested positive for ESBL encoding genes by Check-MDR array, which corresponds to 91.8% (67/73) of the total Enterobacteriaceae and 10.3% (4/39) of nonfermenting Gram-negative bacilli. Among the total ESBL gene positive isolates, 95.8% (68/71) carried bla

conclusionsThis study demonstrates a remarkably high prevalence of bla

Indexed as

AminoglycosidesAnti-Bacterial Agentsbeta-LactamasesEnterobacteriaceaeEnterobacteriaceae InfectionsEthiopiaFluoroquinolonesGene FrequencyGenotypeHumansMicrobial Sensitivity TestsPrevalenceAminoglycosidesAnti-Bacterial Agentsbeta-Lactamasesbeta-lactamase TEM-3FluoroquinolonesAntimicrobial susceptibilityCTX-MEthiopiaExtended-spectrum beta-lactamaseGram-negative bacilli

Identifiers

PMID30342476
PMCPMC6196031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.