ArticleNeurobiology of aging2019
Dissociable effects of the apolipoprotein-E (APOE) gene on short- and long-term memories.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL.NPJ digital medicine · 2026Article
- Associations Between Klotho Levels,Schizophrenia bulletin open · 2025Article
- Apolipoprotein E epsilon4 allele is associated with better performance language and visual memory in spinocerebellar ataxia type 3.European journal of neurology · 2025Article
- Longitudinal effects of sex differences and apolipoprotein E genotype on white matter engagement among elderly.Brain communications · 2025Article
- Demands on perceptual and mnemonic fidelity are a key determinant of age-related cognitive decline throughout the lifespan.Journal of experimental psychology. General · 2024Article
- Comparing the impact of contextual associations and statistical regularities in visual search and attention orienting.PloS one · 2024Article
- Dissociable effects of mild COVID-19 on short- and long-term memories.Brain communications · 2024Article
- Disrupted excitation-inhibition balance in cognitively normal individuals at risk of Alzheimer's disease.bioRxiv : the preprint server for biology · 2023Article
- The Relationship between Short- and Long-Term Memory Is Preserved across the Age Range.Brain sciences · 2023Article
- Disrupted Excitation-Inhibition Balance in Cognitively Normal Individuals at Risk of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Dissociable effects ofNature aging · 2021Article
- Superior short-term memory in APOE ε2 carriers across the age range.Behavioural brain research · 2021Article
- Memory precision of object-location binding is unimpaired inBrain communications · 2021Article
- A meta-analysis of Alzheimer's disease's relationship with human ApoE gene variants.American journal of translational research · 2021Review
- Improving Drug Delivery for Alzheimer's Disease Through Nose-to-Brain Delivery Using Nanoemulsions, Nanostructured Lipid Carriers (NLC) and in situ Hydrogels.International journal of nanomedicine · 2021Review
- A new toolbox to distinguish the sources of spatial memory error.Journal of vision · 2020Article
- Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Short-term memory advantage for brief durations in human APOE ε4 carriers.Scientific reports · 2020Article
- Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma.Oncology letters · 2020Article
- Impaired memory-guided attention in asymptomatic APOE4 carriers.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Short- and long-term memory performance as a function of apolipoprotein-E (APOE) genotype was examined in older, healthy individuals using sensitive and comparable tasks to provide a more detailed description of influences of the ε4 allele (highest genetic risk factor for Alzheimer's disease) on memory. Older heterozygous and homozygous ε4 carriers and noncarriers performed 2 tasks of memory. Both tasks allowed us to measure memory for item identity and locations, using a sensitive, continuous measure of report. Long-term memory for object locations was impaired in ε4/ε4 carriers, whereas, paradoxically, this group demonstrated superior short-term memory for locations. The dissociable effects of the gene on short- and long-term memory suggest that the effect of genotype on these two types of memories, and their neural underpinnings, might not be co-extensive. Whereas the long-term memory impairment might be linked to preclinical Alzheimer's disease, the short-term memory advantage may reflect an independent, phenotypical effect of this allele on cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.