ArticleBritish journal of pharmacology2019
The affinity, intrinsic activity and selectivity of a structurally novel EP
Article in British journal of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Ligand-based machine learning models to classify active compounds for prostaglandin EP2 receptor.Scientific reports · 2026Article
- Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.Journal of neuroinflammation · 2024Article
- Constitutive internalisation of EP2 differentially regulates G protein signalling.Journal of molecular endocrinology · 2024Article
- Functional rewiring of G protein-coupled receptor signaling in human labor.Cell reports · 2022Article
- Do AutoML-Based QSAR Models Fulfill OECD Principles for Regulatory Assessment? A 5-HTPharmaceutics · 2022Article
- The role of EPThe British journal of ophthalmology · 2021Article
- Agonism of Prostaglandin E2 Receptor 4 Ameliorates Tubulointerstitial Injury in Nephrotoxic Serum Nephritis in Mice.Journal of clinical medicine · 2021Article
- Drug discovery strategies for the identification of novel regulators of uterine contractility.Current opinion in physiology · 2020Article
- The affinity, intrinsic activity and selectivity of a structurally novel EPBritish journal of pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeProstanoid EP EXPERIMENTAL APPROACH: The pharmacology of a series of non-prostanoid EP KEY
resultsPGN-9856 was a selective and high affinity (pKi ≥ 8.3) ligand at human recombinant EP CONCLUSIONS AND IMPLICATIONS: PGN-9856 is a potent, selective and efficacious prostanoid EP
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.