ArticleClinical research in cardiology : official journal of the German Cardiac Society2019
Prognostic value of estimated plasma volume in acute heart failure in three cohort studies.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Angiotensin-converting-enzyme inhibitors in hemodynamic congestion: a meta-analysis of early studies.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Pooled it
- Aprocitentan in Patients With Chronic Kidney Disease and Resistant Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Estimated Plasma Volume Status May Modify the Association between Estimated Glomerular Filtration Rate and Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction: A post hoc Analysis of the TOPCAT Trial.Cardiorenal medicine · 2026Trial
- Prognostic implications of a four-group classification based on estimated plasma volume status and creatinine in acute heart failure.Heart and vessels · 2026Article
- Prognostic Significance of Estimated Plasma Volume Status in Patients with Heart Failure: A Systematic Review and Meta-Analysis.Acta Cardiologica Sinica · 2026Article
- Association Between Insulin Therapy and In-Hospital Death in Chronic Heart Failure Patients With Type 2 Diabetes Mellitus: Mediated by Plasma Volume.Journal of diabetes · 2025Article
- Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Factors contributing to transient and persistent worsening renal function in elderly patients with acute decompensated heart failure.Journal of cardiothoracic surgery · 2025Article
- Nonlinear association between estimated plasma volume status and acute kidney injury in acute pancreatitis patients.World journal of gastroenterology · 2025Article
- Predictive value of blood urea nitrogen to creatinine ratio and estimated plasma volume status in heart failure.BMC cardiovascular disorders · 2025Article
- The Role of the Estimated Plasma Volume Variation in Assessing Decongestion in Patients with Acute Decompensated Heart Failure.Biomedicines · 2025Article
- High-level ePVS was accompanied by an increase in kidney transplant failure risk: analysis based on the MIMIC-IV database.Frontiers in immunology · 2025Article
- Estimated plasma volume status as a simple and accessible predictor of 28-day mortality in septic shock: insights from a retrospective study of the MIMIC-IV database.Frontiers in medicine · 2024Article
- Estimated plasma volume status adds prognostic value to hemodynamic parameters in advanced heart failure.Internal and emergency medicine · 2023Article
- Estimated plasma volume status as a prognostic marker in patients with lower extremity artery disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Heart Failure Pharmacological Management: Gaps and Current Perspectives.Journal of clinical medicine · 2023Article
- New Classification for the Combined Assessment of the Fractional Excretion of Urea Nitrogen and Estimated Plasma Volume Status in Acute Heart Failure.Journal of the American Heart Association · 2023Article
- Bedside Prognostication in Decompensated Heart Failure: No "Easy Button".Journal of the American Heart Association · 2023Article
- Effect of estimated plasma volume status and left atrial diameter on prognosis of patients with acute heart failure.Frontiers in cardiovascular medicine · 2023Article
- Calculated plasma volume status is associated with poor outcomes in acute ischemic stroke treated with endovascular treatment.Frontiers in neurology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
aimsEstimated plasma volume status (ePVS) predicts prognosis in patients with heart failure (HF). It remains unclear whether admission, discharge or change ePVS best predicts post-discharge outcome in patients with acute decompensated heart failure (ADHF).
methodsWe retrospectively analyzed three cohort studies: 383 patients admitted at the Tokyo Medical University hospital, 165 patients admitted at the Centro Hospitalar do Porto and 164 patients admitted at the Nancy University Hospital (ICALOR study). ePVS at admission and at discharge as well as its change thereof were, respectively, calculated using the Duarte and Strauss formulas, both derived from hemoglobin and hematocrit ratios. Clinical variables including physical assessment, biological and echocardiographic parameters were recorded. The clinical outcome was a composite of re-hospitalization for worsening HF or all-cause mortality [corrected].
resultsThe primary outcomes occurred in 27.2% at 1 year (in the Tokyo cohort), 45.3% at 6 months (in the Porto cohort) and 53.9% at median terms of 298.3 days (in the ICALOR study). After adjusting for potential confounders including natriuretic peptide, discharge ePVS remained significantly associated with increased rates of composite outcome in the Tokyo and Porto cohorts and ICALOR study [hazard ratio (HR) 1.21 (1.01-1.44), p = 0.04; HR 1.45 (1.16-1.81), p < 0.01; HR 1.45 (1.16-1.81), p < 0.01, respectively]. In addition, a pooled analysis yielded a significant improvement in reclassification with discharge ePVS [net reclassification index 13.6% (5.9-22.7), p = 0.004].
conclusionsAs validated in three independent ADHF cohorts, ePVS at discharge was independently associated with post-discharge clinical outcomes and improved the risk stratification of patients admitted for ADHF on top of well-established prognostic markers.
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