Evidence map›Paper›PMID 30341415›Full record

ArticleCancer gene therapy2019

MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells.

Nisansala Chandimali, Do Luong Huynh, Jiao Jiao Zhang, Jae Cheol Lee, Dae-Yeul Yu, Dong Kee Jeong, Taeho Kwon

Open access · hybridAbstract read
In one paragraph

Article in Cancer gene therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Role of miRNA‑122 in cancer (Review).International journal of oncology · 2024
    Review
  6. The Impact of miR-122 on Cancer.Current pharmaceutical biotechnology · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. [Targeted killing of CD133Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Targeting cancer stem cell pathways for cancer therapy.Signal transduction and targeted therapy · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nisansala ChandimaliLaboratory of Animal Genetic Engineering and Stem Cell Biology, Advanced Convergence Technology and Science, Jeju National University, Jeju, 63243, Republic of Korea.
Do Luong HuynhLaboratory of Animal Genetic Engineering and Stem Cell Biology, Advanced Convergence Technology and Science, Jeju National University, Jeju, 63243, Republic of Korea.ORCID http://orcid.org/0000-0002-4821-7271
Jiao Jiao ZhangLaboratory of Animal Genetic Engineering and Stem Cell Biology, Advanced Convergence Technology and Science, Jeju National University, Jeju, 63243, Republic of Korea.ORCID http://orcid.org/0000-0002-2699-6729
Jae Cheol LeeAsan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 05505, Republic of Korea.
Dae-Yeul YuDisease Model Research Laboratory, Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
Dong Kee JeongLaboratory of Animal Genetic Engineering and Stem Cell Biology, Advanced Convergence Technology and Science, Jeju National University, Jeju, 63243, Republic of Korea. ngejeong@gmail.com.
Taeho KwonLaboratory of Animal Genetic Engineering and Stem Cell Biology, Advanced Convergence Technology and Science, Jeju National University, Jeju, 63243, Republic of Korea. taehokwonk@gmail.com.ORCID http://orcid.org/0000-0001-9489-0283
Jeju National University · KRAsan Medical Center · KRKorea Research Institute of Bioscience and Biotechnology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we demonstrated that Prx II is important for survival of the gefitinib-resistant A549 (A549/GR) cell line, an NSCLC cell line derived by repeated exposure to gefitinib. Therefore, in this study, we used A549/GR cells to investigate the role of Prx II in GR NSCLC stemness. Initially, to explore the stemness characteristics and investigate the association of Prx II with those stemness characteristics, we successfully isolated a stem cell-like population from A549/GR cells. A549/GR CD133

Indexed as

Gene Expression Regulation, NeoplasticAC133 AntigenAnimalsApoptosisCarcinoma, Non-Small-Cell LungCell Line, TumorCell ProliferationDrug Resistance, NeoplasmGefitinibGene Knockdown TechniquesHumansLung NeoplasmsMiceMicroRNAsNeoplastic Stem CellsNeovascularization, PathologicAC133 AntigenGefitinibMicroRNAsMIRN122 microRNA, humanPeroxiredoxinsReceptors, Notch

Identifiers

PMID30341415
PMCPMC6760639
OpenAlexW2897058279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.