Evidence map›Paper›PMID 30341414›Full record

ArticlePediatric research2018

Impaired antimicrobial response and mucosal protection induced by ibuprofen in the immature human intestine.

Emanuela Ferretti, Eric Tremblay, Marie-Pierre Thibault, Sepideh Fallah, David Grynspan, Karolina M Burghardt, Marcos Bettolli, Corentin Babakissa, Emile Levy, Jean-François Beaulieu

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Emanuela FerrettiDivision of Neonatology, Department of Pediatrics, CHEO, Ottawa, ON, Canada.
Eric TremblayLaboratory of Intestinal Physiopathology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Marie-Pierre ThibaultLaboratory of Intestinal Physiopathology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Sepideh FallahLaboratory of Intestinal Physiopathology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
David GrynspanDepartment of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada.
Karolina M BurghardtDepartment of Women and Children's Program, Brockville General Hospital, Brockville, ON, Canada.
Marcos BettolliDepartment of Surgery, CHEO, University of Ottawa, Ottawa, ON, Canada.
Corentin BabakissaDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Emile LevyDepartment of Nutrition, Centre de Recherche, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada.
Jean-François BeaulieuLaboratory of Intestinal Physiopathology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada. Jean-Francois.Beaulieu@usherbrooke.ca.
Université de Sherbrooke · CAUniversity of Ottawa · CAUniversité de Montréal · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundThe use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin (INDO) and ibuprofen (IBU) has been shown to be an effective therapy for the closure of patent ductus arteriosus (PDA). However, this treatment has been associated with an increased risk of developing enteropathies in neonates. Whether the use of IBU is safer than INDO for the immature intestine remains to be elucidated.

methodsThe direct impact of IBU on the human immature intestinal transcriptome was investigated using serum-free organ culture. Differentially expressed genes were analyzed with Ingenuity Pathway Analysis software and compared with those previously reported with INDO. Validation of differentially expressed genes was confirmed by qPCR.

resultsWe identified several biological processes that were significantly modulated by IBU at similar levels to what had previously been observed with INDO, while the expression of genes involved in "antimicrobial response" and "mucus production" was significantly decreased exclusively by IBU in the immature intestine.

conclusionsOur findings indicate that IBU has a harmful influence on the immature intestine. In addition to exerting many of the INDO observed deleterious effects, IBU alters pathways regulating microbial colonization and intestinal epithelial defense.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCulture Media, Serum-FreeDinoprostoneDose-Response Relationship, DrugDuctus Arteriosus, PatentFetusGene Expression ProfilingGene Expression RegulationGlycolysisHumansIbuprofenIntestinal MucosaIntestinesIntestine, SmallLipid MetabolismOligonucleotide Array Sequence AnalysisAnti-Inflammatory Agents, Non-SteroidalCulture Media, Serum-FreeDinoprostoneIbuprofenOxidoreductases

Identifiers

PMID30341414
OpenAlexW2897295943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.