ArticleInternational journal of obesity (2005)2019
Fetal exposure to maternal active and secondhand smoking with offspring early-life growth in the Healthy Start study.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories.Pediatric obesity · 2025Article
- Patterns and predictors of orbitofrontal sulcogyral morphology in a nonclinical population.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Long-term adverse influence of smoking during pregnancy on height and body size of offspring at ten years old in the UK Biobank cohort.SSM - population health · 2023Article
- Association of Maternal BMI and Rapid Infant Weight Gain With Childhood Body Size and Composition.Pediatrics · 2023Article
- Early-life exposure to tobacco and childhood adiposity: Identifying windows of susceptibility.Pediatric obesity · 2022Article
- Prenatal exposure to tobacco and adverse birth outcomes: effect modification by folate intake during pregnancy.Maternal health, neonatology and perinatology · 2022Article
- Maternal tobacco smoking and offspring autism spectrum disorder or traits in ECHO cohorts.Autism research : official journal of the International Society for Autism Research · 2022Article
- Maternal Urinary Cotinine Concentrations During Pregnancy Predict Infant BMI Trajectory After Birth: Analysis of 89617 Mother-Infant Pairs in the Japan Environment and Children's Study.Frontiers in endocrinology · 2022Article
- Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring.Children (Basel, Switzerland) · 2021Review
- Joint effects of ambient air pollution and maternal smoking on neonatal adiposity and childhood BMI trajectories in the Healthy Start study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Active and Passive Maternal Smoking During Pregnancy and Birth Outcomes: A Study From a Developing Country.Annals of global health · 2021Article
- NURR1 Alterations in Perinatal Stress: A First Step towards Late-Onset Diseases? A Narrative Review.Biomedicines · 2020Review
- Review
- Prenatal Exposure to Tobacco and Offspring Neurocognitive Development in the Healthy Start Study.The Journal of pediatrics · 2020Observational
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have modeled the association between fetal exposure to tobacco smoke and body mass index (BMI) growth trajectories, but not the timing of catch-up growth. Research on fetal exposure to maternal secondhand smoking is limited.
objectivesTo explore the associations between fetal exposure to maternal active and secondhand smoking with body composition at birth and BMI growth trajectories through age 3 years.
methodsWe followed 630 mother-child pairs enrolled in the Healthy Start cohort through age 3 years. Maternal urinary cotinine was measured at ~ 27 weeks gestation. Neonatal body composition was measured using air displacement plethysmography. Child weight and length/height were abstracted from medical records. Linear regression models examined the association between cotinine categories (no exposure, secondhand smoke, active smoking) with weight, fat mass, fat-free mass, and percent fat mass at birth. A mixed-effects regression model estimated the association between cotinine categories and BMI.
resultsCompared to unexposed offspring, birth weight was significantly lower among offspring born to active smokers (-343-g; 95% CI: -473, -213), but not among offspring of women exposed to secondhand smoke (-47-g; 95% CI: -130, 36). There was no significant difference in the rate of BMI growth over time between offspring of active and secondhand smokers (p = 0.58). Therefore, our final model included a single growth rate parameter for the combined exposure groups of active and secondhand smokers. The rate of BMI growth for the combined exposed group was significantly more rapid (0.27 kg/m
conclusionsOffspring prenatally exposed to maternal active or secondhand smoking experience rapid and similar BMI growth in the first three years of life. Given the long-term consequences of rapid weight gain in early childhood, it is important to encourage pregnant women to quit smoking and limit their exposure to secondhand smoke.
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