Evidence map›Paper›PMID 30341390›Full record

ArticleScientific reports2018

Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients.

Yevgeniy Freyvert, Nicholas Au Yong, Erika Morikawa, Sharon Zdunowski, Melanie E Sarino, Yury Gerasimenko, V Reggie Edgerton, Daniel C Lu

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06773286 narecruitingnot on this mapstarted 2024, after this paper: background citation

Establishing the Feasibility, Safety, and Efficacy of Spinal Cord Transcutaneous Stimulation with Activity-based Training for Upper Extremity Function Recovery in Individuals with Acute to Subacute Tetraplegia

TypeinterventionalSponsorKessler FoundationRan2024 to 2025Enrolled30ConditionsSpinal Cord Injury CervicalArmsActive Stimulation, Sham, Training only
NCT07208188 early_phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Transcutaneous Spinal Cord Stimulation for Rehabilitation of Upper Limbs in Early Spinal Cord Injury: Randomised Feasibility Study

TypeinterventionalSponsorNHS Greater Glasgow and ClydeRan2025 to 2027Enrolled20ConditionsSpinal Cord Injuries (SCI)ArmsTranscutaneous spinal cord stimulation (tESCS) active group, Sham transcutaneous spinal cord stimulation (tESCS)
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
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  14. Cardiovascular safety of transcutaneous spinal cord stimulation in cervical spinal cord injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  15. Review
  16. Review
  17. Long-Term 5-HTInternational journal of molecular sciences · 2024
    Article
  18. Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yevgeniy FreyvertDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Nicholas Au YongDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Erika MorikawaDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Sharon ZdunowskiDepartments of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Melanie E SarinoRancho Los Amigos National Rehabilitation Center, Downey, California, 90242, USA.
Yury GerasimenkoDepartments of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, 90095, USA.
V Reggie EdgertonDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, 90095, USA.
Daniel C LuDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, California, 90095, USA. dclu@mednet.ucla.edu.
University of California, Los Angeles · USRancho Los Amigos National Rehabilitation Center · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Enabling forelimb function with agonist drug and epidural stimulation in SCIU01EB015521 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EDGERTON, REGGIE, LU, DANIEL · 2013 to 2017
$6.0M
Transformation of Paraplegic Paralysis to Overground Stepping in HumansR01NS102920 · NINDS · UNIVERSITY OF LOUISVILLE · PI OVECHKIN, ALEXANDER VLADIMIROVICH · 2019 to 2023
$2.8M
NCATS NIH HHS UL1 TR000124NIBIB NIH HHS U01 EB015521NINDS NIH HHS R01 NS102920
6 · The paper itself

Abstract

The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated through measures of controlled hand contraction, handgrip force production, dexterity measures, and validated clinical assessment batteries. Repeated measure analysis of variance was used to evaluate functional metrics, EMG amplitude, and changes in mean grip strength. In aggregate, mean hand strength increased by greater than 300% with transcutaneous electrical stimulation and buspirone while a corresponding clinically significant improvement was observed in upper extremity motor scores and the action research arm test. Some functional improvements persisted for an extended period after the study interventions were discontinued. We demonstrate that, with these novel interventions, cervical spinal circuitry can be neuromodulated to improve volitional control of hand function in tetraplegic subjects. The potential impact of these findings on individuals with upper limb paralysis could be dramatic functionally, psychologically, and economically.

Indexed as

Electric Stimulation TherapyMovementRecovery of FunctionAdolescentAdultBuspironeCombined Modality TherapyEvoked Potentials, MotorFemaleHandHand StrengthHumansMaleNeck InjuriesSerotonin Receptor AgonistsSpinal Cord InjuriesBuspironeSerotonin Receptor Agonists

Identifiers

PMID30341390
PMCPMC6195617
OpenAlexW2896759242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.