Evidence map›Paper›PMID 30341350›Full record

ArticleScientific reports2018

Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells.

Carolin N Zorn, Anne Simonowski, Michael Huber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Carolin N ZornInstitute of Biochemistry and Molecular Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Anne SimonowskiInstitute of Biochemistry and Molecular Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Michael HuberInstitute of Biochemistry and Molecular Immunology, Faculty of Medicine, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany. mhuber@ukaachen.de.
RWTH Aachen University · DE

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) HU794/10-1Deutsche Forschungsgemeinschaft (German Research Foundation) SFB 620 B7
6 · The paper itself

Abstract

Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central positive and negative regulators of Ag-triggered MC activation, respectively, contrarily controlling Ca

Indexed as

Agammaglobulinaemia Tyrosine KinaseAnimalsAntigensBone Marrow CellsCalciumCell DegranulationCytokinesDiglyceridesEnzyme ActivationExtracellular Signal-Regulated MAP KinasesImmunoglobulin EMast CellsMicePhenotypePhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesAgammaglobulinaemia Tyrosine KinaseAntigensBtk protein, mouseCalciumCytokinesDiglyceridesExtracellular Signal-Regulated MAP KinasesImmunoglobulin EInpp5d protein, mousePhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesPhospholipase C gammaReceptors, IgE

Identifiers

PMID30341350
PMCPMC6195619
OpenAlexW2897181864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.