ArticleScientific reports2018
White-nose syndrome is associated with increased replication of a naturally persisting coronaviruses in bats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Viral Co-Infection in Bats: A Systematic Review.Viruses · 2023Pooled it
- Coronavirus sampling and surveillance in bats from 1996-2019: a systematic review and meta-analysis.Nature microbiology · 2023Pooled it
- Going wild: prioritizing experimental models of rodent-borne viruses to decode zoonotic spillover and pandemic risk.Journal of virology · 2026Review
- Proteomic Signatures of SARS-CoV-2 Susceptibility in Mexican Free-tailed Bats and Their Application to Viral Surveillance.Integrative and comparative biology · 2025Article
- Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Journal of virology · 2025Article
- Role of individual and population heterogeneity in shaping dynamics of multi-pathogen shedding in an island endemic bat.PLoS pathogens · 2025Article
- Co-Infections with Orthomarburgviruses, Paramyxoviruses, and Orthonairoviruses in Egyptian Rousette Bats, Uganda and Sierra Leone.Emerging infectious diseases · 2025Article
- Vulnerability of Southern Hemisphere bats to white-nose syndrome based on global analysis of fungal host specificity and cave temperatures.Conservation biology : the journal of the Society for Conservation Biology · 2025Article
- Molecular epidemiology ofMicrobial genomics · 2025Article
- Signals of positive selection in genomes of palearctic Myotis-bats coexisting with a fungal pathogen.BMC genomics · 2024Article
- Impact of putatively beneficial genomic loci on gene expression in little brown bats (Evolutionary applications · 2024Article
- Risk Communication on Zoonoses and Antimicrobial Resistance-How Do Exotic Pet Owners Perceive the Communication of Their Veterinarians?Animals : an open access journal from MDPI · 2024Article
- Advances in understanding bat infection dynamics across biological scales.Proceedings. Biological sciences · 2024Review
- Effects of ophidiomycosis on movement, survival, and reproduction of eastern foxsnakes (Pantherophis vulpinus).Scientific reports · 2024Article
- Human disturbance increases coronavirus prevalence in bats.Science advances · 2023Article
- Synchronicity of viral shedding in molossid bat maternity colonies.Epidemiology and infection · 2023Article
- Oral Sampling of Little Brown BatAnimals : an open access journal from MDPI · 2023Article
- White-Nose Syndrome Disrupts the Splenic Lipidome of Little Brown Bats (Journal of proteome research · 2023Article
- Review
- Experimental Infection of Brazilian Free-Tailed Bats (Viruses · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spillover of viruses from bats to other animals may be associated with increased contact between them, as well as increased shedding of viruses by bats. Here, we tested the prediction that little brown bats (Myotis lucifugus) co-infected with the M. lucifugus coronavirus (Myl-CoV) and with Pseudogymnoascus destructans (Pd), the fungus that causes bat white-nose syndrome (WNS), exhibit different disease severity, viral shedding and molecular responses than bats infected with only Myl-CoV or only P. destructans. We took advantage of the natural persistence of Myl-CoV in bats that were experimentally inoculated with P. destructans in a previous study. Here, we show that the intestines of virus-infected bats that were also infected with fungus contained on average 60-fold more viral RNA than bats with virus alone. Increased viral RNA in the intestines correlated with the severity of fungus-related pathology. Additionally, the intestines of bats infected with fungus exhibited different expression of mitogen-activated protein kinase pathway and cytokine related transcripts, irrespective of viral presence. Levels of coronavirus antibodies were also higher in fungal-infected bats. Our results suggest that the systemic effects of WNS may down-regulate anti-viral responses in bats persistently infected with M. lucifugus coronavirus and increase the potential of virus shedding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.