ArticleScientific reports2018
The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Molecular Mechanisms of Algicidal Bacteria in Controlling Harmful Algal Blooms: Advances in Bacteria-Algae Interactions.Environmental microbiology reports · 2026Review
- Cycloprodigiosin: A multispecies settlement cue for scleractinian coral larvae.Scientific reports · 2025Article
- Direct observation and quantitative characterization of chemotactic behaviors in Caribbean coral larvae exposed to organic and inorganic settlement cues.Scientific reports · 2025Article
- Antibacterial Marinopyrroles and Pseudilins Act as Protonophores.ACS chemical biology · 2024Article
- Algal blooms in the ocean: hot spots for chemically mediated microbial interactions.Nature reviews. Microbiology · 2024Review
- Linking bacterial tetrabromopyrrole biosynthesis to coral metamorphosis.ISME communications · 2023Article
- Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease.Communications biology · 2023Article
- Coral settlement induction by tetrabromopyrrole is widespread among Caribbean corals and compound specific.Frontiers in Marine Science · 2023Article
- Flavobacterial exudates disrupt cell cycle progression and metabolism of the diatom Thalassiosira pseudonana.The ISME journal · 2022Article
- Coccolith Sr/Ca is a robust temperature and growth rate indicator that withstands dynamic microbial interactions.Geobiology · 2022Article
- Resolving the Microalgal Gene Landscape at the Strain Level: a Novel Hybrid Transcriptome ofApplied and environmental microbiology · 2022Article
- Algicidal Bacteria: A Review of Current Knowledge and Applications to Control Harmful Algal Blooms.Frontiers in microbiology · 2022Review
- Pelagic diatoms communicate through synchronized beacon natural fluorescence signaling.Science advances · 2021Article
- Marine and Anthropogenic Bromopyrroles Alter Cellular CaEnvironmental science & technology · 2021Article
- Identification and analysis of the biological activity of the new strain of Pseudoalteromonas piscicida isolated from the hemal fluid of the bivalve Modiolus kurilensis (F. R. Bernard, 1983).Archives of microbiology · 2021Article
- Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.Scientific reports · 2020Article
- Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis-inducing factors.Environmental microbiology · 2020Article
- Bacterial alkylquinolone signaling contributes to structuring microbial communities in the ocean.Microbiome · 2019Article
- Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein.Biochemistry · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Eukaryotic phytoplankton contribute to the flow of elements through marine food webs, biogeochemical cycles, and Earth's climate. Therefore, how phytoplankton die is a critical determinate of the flow and fate of nutrients. While heterotroph grazing and viral infection contribute to phytoplankton mortality, recent evidence suggests that bacteria-derived cues also control phytoplankton lysis. Here, we report exposure to nanomolar concentrations of 2,3,4,5-tetrabromopyrrole (TBP), a brominated chemical cue synthesized by marine γ-proteobacteria, resulted in mortality of seven phylogenetically-diverse phytoplankton species. A comparison of nine compounds of marine-origin containing a range of cyclic moieties and halogenation indicated that both a single pyrrole ring and increased bromination were most lethal to the coccolithophore, Emiliania huxleyi. TBP also rapidly induced the production of reactive oxygen species and the release of intracellular calcium stores, both of which can trigger the activation of cellular death pathways. Mining of the Ocean Gene Atlas indicated that TBP biosynthetic machinery is globally distributed throughout the water column in coastal areas. These findings suggest that bacterial cues play multiple functions in regulating phytoplankton communities by inducing biochemical changes associated with cellular death. Chemically-induced lysis by bacterial infochemicals is yet another variable that must be considered when modeling oceanic nutrient dynamics.
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