ArticleScientific reports2018
16S rRNA amplicon sequencing reveals a polymicrobial nature of complicated claw horn disruption lesions and interdigital phlegmon in dairy cattle.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- An experimental infection model for rapid reproduction of treponeme-associated hoof disease in captive elk (Microbiology spectrum · 2026Article
- Bacterial community analysis of treponeme-associated hoof disease in free-ranging elk (Applied and environmental microbiology · 2025Article
- Radiomics prediction of surgery in ulcerative colitis refractory to medical treatment.Techniques in coloproctology · 2025Article
- Profiling bacterial communities in feedlot cattle affected with bovine foot rot and bovine digital dermatitis lesions using 16S rRNA gene sequencing and quantitative real-time PCR.BMC microbiology · 2025Article
- A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness.Animals : an open access journal from MDPI · 2025Review
- Unveiling the skin microbial guardians and assailants in psoriasis subtypes: a Mendelian randomization study.Archives of dermatological research · 2024Article
- Sex-Induced Changes in Microbial Eukaryotes and Prokaryotes in Gastrointestinal Tract of Simmental Cattle.Biology · 2024Article
- Impact of high-fructose diet and metformin on histomorphological and molecular parameters of reproductive organs and vaginal microbiota of female rat.Scientific reports · 2024Article
- Unravelling the complexity of bovine milk microbiome: insights into mastitis through enterotyping using full-length 16S-metabarcoding.Animal microbiome · 2024Article
- Metabolic Footprint ofPathogens (Basel, Switzerland) · 2024Article
- Adherence and metal-ion acquisition gene expression increases during infection withInfection and immunity · 2024Article
- Delta Radiomic Features Predict Resection Margin Status and Overall Survival in Neoadjuvant-Treated Pancreatic Cancer Patients.Annals of surgical oncology · 2024Article
- Characterization of the hoof bacterial communities in feedlot cattle affected with digital dermatitis, foot rot or both using a surface swab technique.Animal microbiome · 2024Article
- Feasibility of 16S rRNA sequencing for cerebrospinal fluid microbiome analysis in cattle with neurological disorders: a pilot study.Veterinary research communications · 2023Article
- Bacterial culture and susceptibility of samples taken from septic foot lesions of adult beef cattle.Journal of veterinary internal medicine · 2023Article
- The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions.Microbiome · 2023Article
- Comprehensive Analyses of the Bacterial Population in Non-Healing Claw Lesions of Dairy Cattle.Animals : an open access journal from MDPI · 2022Article
- Plant-derived tormentic acid alters the gut microbiota of the silkworm (Bombyx mori).Scientific reports · 2022Article
- First description of interdigital hyperplasia associated with contagious ovine digital dermatitis in two sheep.Frontiers in veterinary science · 2022Article
- Identification of Bull Semen Microbiome by 16S Sequencing and Possible Relationships with Fertility.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Lameness represents an intractable problem for the dairy industry. Complicated claw horn disruption lesions, interdigital hyperplasia, and interdigital phlegmon are important lameness causing foot lesions. Their aetiology is multifactorial, but infectious processes are likely implicated in disease pathogenesis. Our aim was to investigate the bacterial profiles of these lesions using 16S rRNA gene sequencing of samples obtained from 51 cattle across ten farms in the UK. In this study, interdigital hyperplasia, interdigital hyperplasia with signs of interdigital dermatitis, interdigital phlegmon, complicated sole ulcers, complicated toe ulcers lesions, and complicated white line lesions were investigated; corresponding healthy skin control samples were also analysed. All diseased tissues displayed reduced microbial richness and diversity (as described by Chao1, Shannon, and Simpson alpha-diversity indices) compared to their healthy skin control samples. Our results confirm the association of Treponema spp with some of these disorders. Other anaerobic bacteria including Fusobacterium spp., Fastidiosipila spp. and Porphyromonas spp. were implicated in the aetiology of all these lesions with the exception of interdigital hyperplasia. Complicated claw horn disruption lesions, and interdigital phlegmon were found to have similar bacterial profiles. Such sharing of bacterial genera suggests many of the infectious agents detected in these foot lesions are acting opportunistically; this finding could contribute towards future treatment and control strategies.
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