Evidence map›Paper›PMID 30341278›Full record

ArticleTranslational psychiatry2018

A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.

L G Hommers, J Richter, Y Yang, A Raab, C Baumann, K Lang, M A Schiele, H Weber, A Wittmann, C Wolf and 24 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 16 institutions in 2 countries.

L G HommersInterdisciplinary Center for Clinical Research, University Hospital of Würzburg, Würzburg, Germany. hommers_l@ukw.de.
J RichterDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
Y YangDepartment of Psychiatry and Psychotherapy & Marburg Center for Mind, Brain and Behavior - MCMBB, Phillips-University Marburg, Marburg, Germany.
A RaabInterdisciplinary Center for Clinical Research, University Hospital of Würzburg, Würzburg, Germany.
C BaumannCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
K LangCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2663-5990
M A SchieleDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
H WeberCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-9421-1292
A WittmannDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
C WolfCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
G W AlpersDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
V AroltDepartment of Psychiatry, University Hospital Münster, Münster, Germany.
K DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
L FehmDepartment of Psychology, Humboldt-University, Berlin, Germany.
T FydrichDepartment of Psychology, Humboldt-University, Berlin, Germany.
A GerlachDepartment of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-6794-5349
A T GlosterDepartment of Psychology, University of Basel, Basel, Switzerland.
A O HammDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
S Helbig-LangDepartment of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
T KircherDepartment of Psychiatry and Psychotherapy & Marburg Center for Mind, Brain and Behavior - MCMBB, Phillips-University Marburg, Marburg, Germany.
T LangDepartment of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
C A Pané-FarréDepartment of Biological and Clinical Psychology/Psychotherapy, University of Greifswald, Greifswald, Germany.
P PauliCenter of Mental Health, Department of Biological Psychology, Clinical Psychology, and Psychotherapy, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0692-6720
B PfleidererDepartment of Clinical Radiology, University Hospital Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-1238-6225
A ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0992-634X
M RomanosCenter of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
B StraubeDepartment of Psychiatry and Psychotherapy & Marburg Center for Mind, Brain and Behavior - MCMBB, Phillips-University Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-9837-0944
A StröhleDepartment of Psychiatry and Psychotherapy, Charité University Medicine, Berlin, Germany.
H-U WittchenInstitute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
S FrantzComprehensive Heart Failure Center (CHFC), University Hospital of Würzburg, Würzburg, Germany.
G ErtlComprehensive Heart Failure Center (CHFC), University Hospital of Würzburg, Würzburg, Germany.
M J LohseComprehensive Heart Failure Center (CHFC), University Hospital of Würzburg, Würzburg, Germany.
U LuekenCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
J DeckertCenter for Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEHumboldt-Universität zu Berlin · DEPhilipps University of Marburg · DEUniversität Greifswald · DECharité - Universitätsmedizin Berlin · DEUniversity Hospital Münster · DEUniversity of Freiburg · DEUniversity of Würzburg · DEDornier Flugzeugwerke (Germany) · DEGoethe University Frankfurt · DEMax Delbrück Center · DETechnische Universität Dresden · DEUniversität Hamburg · DEUniversity of Basel · CHUniversity of Cologne · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of microRNAs modulating noradrenaline transporter gene (SLC6A2) expression may thus lead to altered central and peripheral processing of fear and anxiety. In silico prediction of microRNA regulation of SLC6A2 was confirmed by luciferase reporter assays and identified hsa-miR-579-3p as a regulating microRNA. The minor (T)-allele of rs2910931 (MAF

Indexed as

Gene Expression RegulationAdultAllelesAnxietyBrainBrain MappingConditioning, ClassicalExtinction, PsychologicalFearFemaleGenetic VariationHumansMagnetic Resonance ImagingMaleMicroRNAsNorepinephrineMicroRNAsMIRN579 microRNA, humanNorepinephrineNorepinephrine Plasma Membrane Transport ProteinsSLC6A2 protein, human

Identifiers

PMID30341278
PMCPMC6195525
OpenAlexW2898031818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.