Evidence map›Paper›PMID 30341182›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Changes in Brainstem Pain Modulation Circuitry Function over the Migraine Cycle.

Kasia K Marciszewski, Noemi Meylakh, Flavia Di Pietro, Emily P Mills, Vaughan G Macefield, Paul M Macey, Luke A Henderson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kasia K MarciszewskiDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.
Noemi MeylakhDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.
Flavia Di PietroDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.ORCID 0000-0002-9642-0805
Emily P MillsDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia.
Vaughan G MacefieldSchool of Medicine, Western Sydney University, Sydney, 2560 New South Wales, Australia, and.ORCID 0000-0003-3325-6566
Paul M MaceyUCLA School of Nursing and Brain Research Institute, University of California, Los Angeles, California 90095.ORCID 0000-0003-4093-7458
Luke A HendersonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, 2006 New South Wales, Australia, lukeh@anatomy.usyd.edu.au.ORCID 0000-0002-1026-0151
The University of Sydney · AUUniversity of California, Los Angeles · USWestern Sydney University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural mechanism responsible for migraine remains unclear. While an external trigger has been proposed to initiate a migraine, it has also been proposed that changes in brainstem function are critical for migraine headache initiation and maintenance. Although the idea of altered brainstem function has some indirect support, no study has directly measured brainstem pain modulation circuitry function in migraineurs particularly immediately before a migraine. In male and female humans, we performed fMRI in 31 controls and 31 migraineurs at various times in their migraine cycle. We measured brainstem function during noxious orofacial stimulation and assessed resting-state functional connectivity. First, we found that, in individual migraineurs, pain sensitivity increased over the interictal period but then dramatically decreased immediately before a migraine. Second, despite overall similar pain intensity ratings between groups, in the period immediately before a migraine, compared with controls and other migraine phases, migraineurs displayed greater activation in the spinal trigeminal nucleus during noxious orofacial stimulation and reduced functional connectivity of this region with the rostral ventromedial medulla. Additionally, during the interictal phase, migraineurs displayed reduced activation of the midbrain periaqueductal gray matter and enhanced periaqueductal gray connectivity with the rostral ventromedial medulla. These data support the hypothesis that brainstem sensitivity fluctuates throughout the migraine cycle. However, in contrast to the prevailing hypothesis, our data suggest that, immediately before a migraine attack, endogenous analgesic mechanisms are enhanced and incoming noxious inputs are less likely to reach higher brain centers.

Indexed as

AdultBrain StemFemaleHumansMaleMiddle AgedMigraine DisordersNerve NetPainPain ThresholdYoung Adultbrainstem pain modulationfunctional connectivitymigraineorofacial painperiaqueductal gray matterspinal trigeminal nucleus

Identifiers

PMID30341182
PMCPMC6596255
OpenAlexW2897936275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.