Evidence map›Paper›PMID 30341139›Full record

ArticleBMJ open2018

Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review.

Danielle B Rice, Brian Hutton, Patricia Poulin, Beth A Sproule, Dianna Wolfe, David Moher, Kednapa Thavorn, Gary Garber, Sheena Taha, Amy Porath and 6 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Danielle B Rice *Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0001-5615-7005
Brian Hutton *Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Patricia PoulinOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Beth A SprouleDepartment of Pharmacy, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Dianna WolfeOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
David MoherOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Kednapa ThavornOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Gary GarberOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Sheena TahaCanadian Center on Substance Use and Addiction, Ottawa, Ontario, Canada.
Amy PorathCanadian Center on Substance Use and Addiction, Ottawa, Ontario, Canada.
Melanie WillowsDepartment of Family Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Leila EsmaeilisarajiOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Fatemeh YazdiOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Beverley SheaOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Becky SkidmoreOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
Kimberly CoraceOttawa Hospital Research Institute, Ottawa, Ontario, Canada.
University of Ottawa · CAOttawa Hospital · CACanadian Centre on Substance Use and Addiction · CACentre for Addiction and Mental Health · CA

Funding

CIHR 397976
6 · The paper itself

Abstract

introductionThe opioid crisis has resulted in increasing rates of death caused by problematic opioid use. Current clinical guidelines recommend that individuals with persons with opioid use disorder (OUD) receive pharmacological (eg, opioid agonist therapy) and psychosocial (eg, cognitive behavioural therapy) therapy; however, the best combination of pharmacologic and psychosocial components is not known. Our objective of the planned study is to conduct a comprehensive systematic review to assess the relative benefits of psychosocial interventions as an adjunct to opioid agonist therapy among persons with OUD. METHODS AND ANALYSIS: A comprehensive search for randomised controlled trials published in English or French will be conducted from database inception to March 2018. The search will be conducted in MEDLINE and translated for Embase, PsycINFO and the Cochrane Central Register of Controlled Trials. Two independent reviewers will screen, extract and assess risk of bias of eligible articles. Primary outcomes of interest will be treatment retention and opioid use (based on urinalysis results). Secondary outcomes will include self-reported opioid use, abstinence from illicit drugs, adherence to psychosocial therapy and opioid agonist therapy, risk for sexually transmitted disease, risk for blood borne pathogens, changes in mental health symptoms (eg, depression), measures of craving and changes in patients' quality of life and relevant adverse events. If sufficient data and adequate homogeneity exists, network meta-analyses (NMA) will be performed. ETHICS AND DISSEMINATION: This will be the first systematic review to incorporate NMA to compare psychosocial treatments used as an adjunct to opioid agonist therapy for OUD. Results of this review will inform clinical management of persons with OUD. TRIAL REGISTRATION NUMBER: CRD42018090761.

Indexed as

Systematic Reviews as TopicAgedAnalgesics, OpioidCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedNetwork Meta-Analysis as TopicOpioid-Related DisordersQuality of LifeRandomized Controlled Trials as TopicResearch DesignTreatment Adherence and ComplianceAnalgesics, Opioidaddiction medicinenetwork meta-analysisopioid use disorderpharmacological interventionspsychosocial interventionssystematic review

Identifiers

PMID30341139
PMCPMC6196951
OpenAlexW2896199542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.