Evidence map›Paper›PMID 30341085›Full record

ArticleGenetics2018

Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses.

Kathryn S Evans, Shannon C Brady, Joshua S Bloom, Robyn E Tanny, Daniel E Cook, Sarah E Giuliani, Stephen W Hippleheuser, Mostafa Zamanian, Erik C Andersen

Abstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. High-Throughput Toxicity Screening withEnvironmental science & technology · 2026
    Review
  3. Article
  4. Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin.International journal for parasitology. Drugs and drug resistance · 2022
    Article
  15. Article
  16. Article
  17. IntraspecificNAR genomics and bioinformatics · 2022
    Article
  18. Review
  19. Review
  20. Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside.International journal for parasitology. Drugs and drug resistance · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kathryn S EvansMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-1388-8155
Shannon C BradyMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-3043-1544
Joshua S BloomDepartment of Human Genetics, University of California, Los Angeles, California 90095.ORCID 0000-0002-7241-1648
Robyn E TannyMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0002-0611-3909
Daniel E CookMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.ORCID 0000-0003-3347-562X
Sarah E GiulianiMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.
Stephen W HippleheuserMolecular Biosciences, Northwestern University, Evanston, Illinois 60208.
Mostafa ZamanianDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53705.ORCID 0000-0001-9233-1760
Erik C AndersenMolecular Biosciences, Northwestern University, Evanston, Illinois 60208 erik.andersen@northwestern.edu.ORCID 0000-0003-0229-9651

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Developing Capacity to Evaluate Training Programs via Development of Human, Institutional and Social CapitalT32GM008449 · NIGMS · NORTHWESTERN UNIVERSITY · PI LEONARD, JOSHUA NATHANIEL · 1993 to 2023
$7.8M
Determination of the distribution of fitness effects of mutations in C. elegansR01GM107227 · NIGMS · UNIVERSITY OF FLORIDA · PI BAER, CHARLES F · 2014 to 2017
$1.1M
Uncovering new mechanisms of nematode anthelmintic resistanceK22AI125473 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI ZAMANIAN, MOSTAFA · 2017 to 2018
$269k
Howard Hughes Medical InstituteNIAID NIH HHS K22 AI125473NIGMS NIH HHS R01 GM107227NIGMS NIH HHS T32 GM008061NIGMS NIH HHS T32 GM008449
6 · The paper itself

Abstract

Phenotypic complexity is caused by the contributions of environmental factors and multiple genetic loci, interacting or acting independently. Studies of yeast and

Indexed as

AllelesAnimalsCaenorhabditis elegansChromosome MappingEpistasis, GeneticGenomicsMetals, HeavyNeurotoxinsPesticidesQuantitative Trait LociMetals, HeavyNeurotoxinsPesticidesC. elegansgenetic interactionspleiotropyQTLtoxin

Identifiers

PMID30341085
PMCPMC6283156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.