ArticleEBioMedicine2018
A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.Neuroscience bulletin · 2026Article
- Genetic and functional insights into long noncoding RNAs in schizophrenia.Molecular psychiatry · 2026Article
- Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk.Psychological medicine · 2025Article
- Exploring risk and protective urban environmental factors on mental health through exposure network mapping.Research square · 2025Article
- DCC in the cerebral cortex is required for cognitive functions in mouse.Brain pathology (Zurich, Switzerland) · 2025Article
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- Symptom-guided multimodal neuroimage fusion patterns in children with attention-deficit/hyperactivity disorder and its potential "brain structure-function-cognition-behavior" pathological pathways.European child & adolescent psychiatry · 2024Article
- Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia.Translational psychiatry · 2024Article
- Unveiling the gut microbiota blueprint of schizophrenia: a multilevel omics approach.Frontiers in psychiatry · 2024Article
- Article
- Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study.Scientific reports · 2022Article
- Multimodal brain deficits shared in early-onset and adult-onset schizophrenia predict positive symptoms regardless of illness stage.Human brain mapping · 2022Article
- Imputed expression of schizophrenia-associated genes and cognitive measures in patients with schizophrenia.Molecular genetics & genomic medicine · 2022Article
- An attention-based hybrid deep learning framework integrating brain connectivity and activity of resting-state functional MRI data.Medical image analysis · 2022Article
- Imaging Genetic Based Mediation Analysis for Human Cognition.Frontiers in neuroscience · 2022Article
- Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains.Frontiers in neuroscience · 2022Review
- Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC.Oxidative medicine and cellular longevity · 2022Article
- DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- NaJournal of neural transmission (Vienna, Austria : 1996) · 2021Review
- The Association Between Lentiform Nucleus Function and Cognitive Impairments in Schizophrenia.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
35 authors at 10 institutions in 3 countries.
Funding
Abstract
backgroundIn the past decades, substantial effort has been made to explore the genetic influence on brain structural/functional abnormalities in schizophrenia, as well as cognitive impairments. In this work, we aimed to extend previous studies to explore the internal mediation pathway among genetic factor, brain features and cognitive scores in a large Chinese dataset.
methodsGray matter (GM) volume, fractional amplitude of low-frequency fluctuations (fALFF), and 4522 schizophrenia-susceptible single nucleotide polymorphisms (SNP) from 905 Chinese subjects were jointly analyzed, to investigate the multimodal association. Based on the identified imaging-genetic pattern, correlations with cognition and mediation analysis were then conducted to reveal the potential mediation pathways.
findingsOne linked imaging-genetic pattern was identified to be group discriminative, which was also associated with working memory performance. Particularly, GM reduction in thalamus, putamen and bilateral temporal gyrus in schizophrenia was associated with fALFF decrease in medial prefrontal cortex, both were also associated with genetic factors enriched in neuron development, synapse organization and axon pathways, highlighting genes including CSMD1, CNTNAP2, DCC, GABBR2 etc. This linked pattern was also replicated in an independent cohort (166 subjects), which although showed certain age and clinical differences with the discovery cohort. A further mediation analysis suggested that GM alterations significantly mediated the association from SNP to fALFF, while fALFF mediated the association from SNP and GM to working memory performance.
interpretationThis study has not only verified the impaired imaging-genetic association in schizophrenia, but also initially revealed a potential genetic-brain-cognition mediation pathway, indicating that polygenic risk factors could exert impact on phenotypic measures from brain structure to function, thus could further affect cognition in schizophrenia.
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