Evidence map›Paper›PMID 30340589›Full record

Observational studyCardiovascular diabetology2018

Hyperglycemia and risk of ventricular tachycardia among patients hospitalized with acute myocardial infarction.

Hoang V Tran, Joel M Gore, Chad E Darling, Arlene S Ash, Catarina I Kiefe, Robert J Goldberg

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  5. Observational
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  10. Dysglycemia and arrhythmias.World journal of diabetes · 2023
    Review
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  13. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hoang V TranDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Joel M GoreDepartment of Internal Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Chad E DarlingDepartment of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Arlene S AshDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Catarina I KiefeDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA.
Robert J GoldbergDepartment of Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA. Robert.goldberg@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
Risk Stratification in Older Persons with Acute Myocardial Infarction: SILVER-AMIR01HL115295 · NHLBI · YALE UNIVERSITY · PI CHAUDHRY, SARWAT I · 2012 to 2016
$11.3M
EHR Anticoagulants PharmacovigilanceR01HL125089 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI YU, HONG · 2015 to 2019
$4.9M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
NCATS NIH HHS UL1 TR001453NCRR NIH HHS U54 RR 026088NHLBI NIH HHS 1R01HL126911-01A1NHLBI NIH HHS 5R01HL115295-05NHLBI NIH HHS 5R01HL125089-02NHLBI NIH HHS R01 HL115295NHLBI NIH HHS R01 HL125089NHLBI NIH HHS R01 HL126911NIH HHS 5UL1TR001453Patient-Centered Outcomes Research Institute ME-1310-07682
6 · The paper itself

Abstract

backgroundLittle is known about the association of hyperglycemia with the development of ventricular tachycardia (VT) in patients hospitalized with acute myocardial infarction (AMI) which we examined in the present study. The objectives of this community-wide observational study were to examine the relation between elevated serum glucose levels at the time of hospital admission for AMI and occurrence of VT, and time of occurrence of VT, during the patient's acute hospitalization.

methodsWe used data from a population-based study of patients hospitalized with AMI at all central Massachusetts medical centers between 2001 and 2011. Hyperglycemia was defined as a serum glucose level ≥ 140 mg/dl at the time of hospital admission. The development of VT was identified from physicians notes and electrocardiographic findings by our trained team of data abstractors.

resultsThe average age of the study population was 70 years, 58.0% were men, and 92.7% were non-Hispanic whites. The mean and median serum glucose levels at the time of hospital admission were 171.4 mg/dl and 143.0, respectively. Hyperglycemia was present in 51.9% of patients at the time of hospital admission; VT occurred in 652 patients (15.8%), and two-thirds of these episodes occurred during the first 48 h after hospital admission (early VT). After multivariable adjustment, patients with hyperglycemia were at increased risk for developing VT (adjusted OR = 1.48, 95% CI = 1.23-1.78). The presence of hyperglycemia was significantly associated with early (multivariable adjusted OR = 1.39, 95% CI = 1.11-1.73) but not with late VT. Similar associations were observed in patients with and without diabetes and in patients with and without ST-segment elevation AMI.

conclusionsEfforts should be made to closely monitor and treat patients who develop hyperglycemia, especially early after hospital admission, to reduce their risk of VT.

Indexed as

Patient AdmissionAgedAged, 80 and overBiomarkersBlood GlucoseFemaleHumansHyperglycemiaIncidenceMaleMassachusettsMiddle AgedNon-ST Elevated Myocardial InfarctionPrognosisRisk AssessmentRisk FactorsBiomarkersBlood GlucoseArrhythmiaGlucoseHyperglycemiaMyocardial infarctionVentricular tachycardia

Identifiers

PMID30340589
PMCPMC6194566
OpenAlexW2895801687

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.