ArticleBMC cancer2018
Clinical characteristics of Japanese patients with epithelioid hemangioendothelioma: a multicenter retrospective study.
Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06680401 (The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets), which is not on this map. Cited by 31 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation of Cytokines and Hormones as Biomarkers for Epithelioid Haemangioendothelioma and Generation of Patient-derived Preclinical Models to Assess the Activity of Anticancer Agents and Validate Novel Therapeutic Targets
Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- Pathological complete remission of pulmonary epithelioid hemangioendothelioma: a case report and literature review.Journal of cardiothoracic surgery · 2026Review
- A rare case report of epithelioid hemangioendothelioma involving both lungs and right atrium with multi-system involvement.Frontiers in medicine · 2026Article
- Clinical and pathological analysis of pulmonary epithelioid vascular endothelial tumor.Open life sciences · 2026Article
- The Diagnostic Dilemma of Incidentally Detected Pulmonary Nodules: A Fatal Case of Pulmonary Epithelioid Hemangioendothelioma.Respirology case reports · 2025Article
- A case of an incidentally discovered epithelioid haemangioendothelioma.Journal of surgical case reports · 2025Article
- Successful management of recurrent multiple intracerebral TFE3-rearranged epithelioid hemangioendothelioma with repeated intervention and active surveillance: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A case of hepatic epithelioid hemangioendothelioma with features resembling those of acute-onset autoimmune hepatitis that was undiagnosed before liver transplantation.Clinical journal of gastroenterology · 2025Article
- Epithelioid Hemangioendothelioma: Treatment Landscape and Innovations for an Ultra-Rare Sarcoma.Current treatment options in oncology · 2025Review
- Clinicopathological features, risk model and prognosis of 115 cases of epithelioid hemangioendothelioma: A single-center study.Frontiers in oncology · 2025Article
- Epithelioid hemangioendothelioma prognosis and outcome: report of two challenging cases.Journal of cardiothoracic surgery · 2024Article
- Metastatic Epithelioid Hemangioendothelioma of the Bone: A Case Report and Literature Review.Cureus · 2024Article
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- Dual immunotherapy alternating with anti-PD-1 antibody plus liposomal doxorubicin show good efficacy in prostate epithelioid hemangioendothelioma: a case report.Frontiers in immunology · 2024Article
- Beyond the rare: a case of pseudomyogenic hemangioendothelioma treated sequentially with everolimus, denosumab, and pazopanib.Einstein (Sao Paulo, Brazil) · 2024Article
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- Update of pediatric bone tumors-notochordal tumors, chondrogenic tumors, and vascular tumors of the bone.Skeletal radiology · 2023Review
- Case report: Surgical treatment of a primary giant epithelioid hemangioendothelioma of the spine with total en-bloc spondylectomy.Frontiers in oncology · 2023Article
- Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center.Future science OA · 2022Article
- Epithelioid hemangioendothelioma of the spine: an analysis of imaging findings.Insights into imaging · 2022Article
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Authors and funding
17 authors at 15 institutions in 1 country.
Funding
Abstract
backgroundEpithelioid hemangioendothelioma is an exceedingly rare sarcoma often occurring as an indolent angiocentric vascular tumor at various anatomic sites. Few reports have evaluated large case series of epithelioid hemangioendothelioma.
methodsWe conducted a retrospective analysis of the clinical data of 42 consecutive patients with epithelioid hemangioendothelioma who were pathologically diagnosed between 1990 and 2014 at 13 Japanese tertiary hospitals. We analyzed their clinical characteristics, tumor features and prognostic factors.
resultsThe study included 22 men and 20 women, with a median age of 54 (range, 18-78) years. Pain was the most common symptom, occurring in 15 (68%) of the 22 symptomatic patients. The median maximum tumor diameter was 4.0 (range, 1.0-12.8) cm. The most commonly involved organs were the liver (81%), lungs (57%), and bones (12%). The overall survival rates were 79.5% at 1 year and 72.0% at 5 years. Substantially better survival was observed in asymptomatic patients than in symptomatic patients (P = 0.03), and better survival was also ovserved in patients with Ki-67 index ≤10% than in those with Ki-67 index > 10% (P = 0.04). By multivariate analysis, tumor size > 3.0 cm was associated with decreased survival (P = 0.049, hazard ratio 13.33).
conclusionsThis study showed the clinical characteristics of Japanese patients with epithelioid hemangioendothelioma. Tumor size > 3.0 cm is an independent indicator of a poor prognosis in epithelioid hemangioendothelioma. The presence of symptoms at the time of diagnosis and high Ki-67 index implied poor survival.
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