ArticleBMC nephrology2018
Pediatric continuous renal replacement therapy: have practice changes changed outcomes? A large single-center ten-year retrospective evaluation.
Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- An epidemiological assessment of hemodialysis, continuous kidney replacement therapy, and peritoneal dialysis in pediatric acute kidney injury patients.Renal failure · 2026Article
- Complications and outcomes of children under one year treated with continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Time from acute kidney injury to continuous renal replacement therapy and outcomes in critically ill children.Clinical kidney journal · 2026Article
- Pediatric continuous kidney replacement therapy: The Indonesian experience.Pediatric nephrology (Berlin, Germany) · 2025Article
- Continuous renal replacement therapy (CRRT) program initiation in PICU of a resource limited setting: a retrospective analysis of challenges and outcomes.BMC nephrology · 2025Article
- Experience of continuous kidney replacement therapy in a tertiary care unit of a lower-middle-income country.Pediatric nephrology (Berlin, Germany) · 2025Article
- Machine Learning-Based Prediction Model for ICU Mortality After Continuous Renal Replacement Therapy Initiation in Children.Critical care explorations · 2024Article
- Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Factors associated with successful liberation from continuous renal replacement therapy in children and young adults: analysis of the worldwide exploration of renal replacement outcomes collaborative in Kidney Disease Registry.Intensive care medicine · 2024Article
- Medication patterns and dosing guidance in pediatric patients supported with intermittent hemodialysis or continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2024Review
- Time to Continuous Renal Replacement Therapy Initiation and 90-Day Major Adverse Kidney Events in Children and Young Adults.JAMA network open · 2024Article
- Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK).Kidney international reports · 2023Article
- Optimal stage of initiating continuous renal replacement therapy in the treatment of neonatal acute kidney injury.Experimental and therapeutic medicine · 2022Article
- Standardizing Care in Pediatric Continuous Kidney Replacement Therapy-Can We Reach Consensus Without Adequate Evidence?JAMA network open · 2022Article
- Hemodynamic instability during connection to continuous kidney replacement therapy in critically ill pediatric patients.Pediatric nephrology (Berlin, Germany) · 2022Article
- Patient-centered outcomes in pediatric continuous kidney replacement therapy: new morbidity and worsened functional status in survivors.Pediatric nephrology (Berlin, Germany) · 2022Article
- Medication based machine learning to identify subpopulations of pediatric hemodialysis patients in an electronic health record database.Informatics in medicine unlocked · 2022Article
- The need for hemodialysis is associated with increased mortality in mechanically ventilated children: a propensity score-matched outcome study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Continuous Renal Replacement Therapy in Critically Ill Children in the Pediatric Intensive Care Unit: A Retrospective Analysis of Real-Life Prescriptions, Complications, and Outcomes.Frontiers in pediatrics · 2021Article
- Lessons Learned from a Small Pediatric Continuous Renal Replacement Therapy Program.Critical care research and practice · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate changes in population characteristics and outcomes in a large single-center pediatric patient cohort treated with continuous renal replacement therapy (CRRT) over a 10 year course, coincident with multiple institutional practice changes in CRRT delivery.
methodsA retrospective cohort study with comparative analysis of all patients treated from 2004 to 2013 with CRRT in the neonatal, pediatric, and cardiovascular intensive care units within a free-standing pediatric tertiary care hospital.
resultsThree hundred eleven total patients were identified, 38 of whom received concurrent treatment with extracorporeal membrane oxygenation. 273 patients received CRRT only and were compared in two study eras (2004-2008 n = 129; 2009-2013 n = 144). Across eras, mean patient age decreased (9.2 vs 7.7 years, p = 0.08), and the most common principal diagnosis changed from cardiac to liver disease. There was an increase in patients treated with continuous renal replacement therapy between cohorts for acute kidney injury of multi factorial etiology (44% vs 56%) and a decrease in treated patients with sepsis (21% vs 11%, p = 0.04). There was no significant difference in survival to hospital discharge between eras (47% vs 49%). Improvement in outpatient follow-up after discharge amongst survivors was seen between study eras (33% vs 54%).
conclusionsDespite multiple institutional practice changes in provision of CRRT, few changes were seen regarding patient demographics, diseases treated, indications for therapy, and survival over 10 years at a single tertiary care. Recognition of need for follow-up nephrology care following CRRT is improving. Ongoing assessment of the patient population in a changing landscape of care for critically ill pediatric patients remains important.
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