Evidence map›Paper›PMID 30340526›Full record

ReviewBMC cardiovascular disorders2018

Native valve endocarditis due to Escherichia coli infection: a case report and review of the literature.

Nobuhiro Akuzawa, Masahiko Kurabayashi

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Infective endocarditis caused byThe Journal of international medical research · 2025
    Article
  3. Review
  4. Review
  5. A case ofIDCases · 2025
    Article
  6. Article
  7. Uncommon pathogens causing infective endocarditis.Indian journal of thoracic and cardiovascular surgery · 2024
    Review
  8. IDCases · 2024
    Article
  9. An enigmatic presentation ofClinical case reports · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Rare Case of Emphysematous Endocarditis Caused bySultan Qaboos University medical journal · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2021
    Review
  19. Article
  20. IDCases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nobuhiro AkuzawaDepartment of General Medicine, National Hospital Organization Shibukawa Medical Center, 383 Shiroi, Shibukawa, Gunma, 377-0280, Japan. akuzawa_nobuhiro@yahoo.co.jp.ORCID 0000-0002-1204-1294
Masahiko KurabayashiDepartment of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.
Gunma University · JPNational Hospital Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfective endocarditis due to Escherichia coli is a rare disease but is increasing in frequency, especially among older women. In addition, its mortality rate is higher than that of endocarditis due to the HACEK-group gram-negative bacteria (Haemophilus spp., Aggregatibacter spp., Cardiobacterium hominis, Eikenella corrodens, and Kingela spp.). CASE PRESENTATION: A 58-year-old Japanese woman with a history of alcohol abuse was admitted to our hospital because of a fever. She was diagnosed with infective endocarditis due to E. coli based on repeated blood cultures and transthoracic echocardiography, which revealed vegetations attached to the anterior leaflet and chordae tendineae of the mitral valve. Despite administration of sulbactam/ampicillin and gentamycin, she developed purulent spondylitis during hospitalization and required treatment with meropenem administration for 6 weeks, leading to resolution of the endocarditis. She took oral levofloxacin for 2 months, and the spondylitis was completely cured 7 months after discharge.

conclusionEscherichia coli affects native valves without degenerative valvulopathy rather than prosthetic valves, especially in patients with risk factors such as an immunosuppressive status, excessive alcohol consumption, or treatment with hemodialysis. Peripheral embolization, congestive heart failure, and valve-ring abscesses are major complications of E. coli endocarditis; notably, infective myocarditis can also occur. The mortality and surgical intervention rates are 21% and 42%, respectively. Physicians should be cognizant of the necessity of surgical intervention when E. coli endocarditis is resistant to antibiotic therapy.

Indexed as

AlcoholismAnti-Bacterial AgentsEchocardiographyEndocarditis, BacterialEscherichia coliEscherichia coli InfectionsFemaleHumansMiddle AgedMitral ValveRemission InductionRisk FactorsSpondylitisSuppurationTime FactorsTreatment OutcomeAnti-Bacterial AgentsEscherichia coliExcessive alcohol consumptionInfective endocarditisPurulent spondylitis

Identifiers

PMID30340526
PMCPMC6194693
OpenAlexW2897068294

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.