Evidence map›Paper›PMID 30340503›Full record

Trial reportBreast cancer research : BCR2018

Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial.

Christina M Dieli-Conwright, Kerry S Courneya, Wendy Demark-Wahnefried, Nathalie Sami, Kyuwan Lee, Frank C Sweeney, Christina Stewart, Thomas A Buchanan, Darcy Spicer, Debu Tripathy and 2 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Breast cancer research : BCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 176 papers, 38 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 38 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01140282 nacompletednot on this map

Combined Exercise Program for Early Breast Cancer Survivors

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2012 to 2018Enrolled106ConditionsStage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast CancerArmsquestionnaire administration, quality-of-life assessment, management of therapy complications, exercise intervention
NCT06004427 nacompletednot on this mapstarted 2023, after this paper: background citation

Investigation of the Effectiveness of Resistance Exercise Program Given With Diet in Obese Individuals.

TypeinterventionalSponsorUskudar UniversityRan2023 to 2023Enrolled50ConditionsObesityArmsDiet program, Exercise training protocols
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 38 syntheses or guidelines pooled it, 310 citations in OpenAlex.

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  2. Efficacy of different non-pharmacological therapies on cancer-related fatigue in breast cancer patients: a network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  11. Effects of resistance training on breast cancer-related arm lymphedema: a systematic review and dose-response meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  18. Effect of therapeutic exercise on peak oxygen consumption in oncological population: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Christina M Dieli-ConwrightDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA. cdieli@usc.edu.ORCID 0000-0001-9093-7259
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, T6G 2H9, Canada.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Nathalie SamiDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Kyuwan LeeDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Frank C SweeneyDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Christina StewartDivision of Biokinesiology and Physical Therapy, University of Southern California (USC), |1540 E. Alcazar St., CHP 155, Los Angeles, CA, 90089, USA.
Thomas A BuchananDivision of Endocrinology and Diabetes, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
Darcy SpicerDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Debu TripathyDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Leslie BernsteinDivision of Biomarkers of Early Detection and Prevention, Beckman Research Institute, City of Hope (COH), Duarte, CA, 91010, USA.
Joanne E MortimerDivision of Medical Oncology and Experimental Therapeutics, COH, Duarte, CA, 91010, USA.
University of Southern California · USCity of Hope · USKeck Hospital of USC · USTherapeutics Clinical Research · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alabama at Birmingham · USUniversity of Alberta · CA

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise InterventionK07CA160718 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DIELI-CONWRIGHT, CHRISTINA · 2011 to 2015
$629k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS K07 CA160718NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

backgroundExercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors.

methodsOne hundred breast cancer survivors within 6 months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis.

resultsAt post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p < 0.001), fatigue (p < 0.001), depression (p < 0.001), estimated VO

conclusionsA 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care.

trial registrationThis trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.

Indexed as

Resistance TrainingAdultBone DensityBreast NeoplasmsCancer SurvivorsExerciseFemaleHumansMiddle AgedObesityPatient Reported Outcome MeasuresPhysical FitnessQuality of LifeTreatment Outcomebone healthbreast cancerExercisephysical fitnessquality of life

Identifiers

PMID30340503
PMCPMC6194749
OpenAlexW2896306379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.