Evidence map›Paper›PMID 30340326›Full record

ArticleViruses2018

Time to Harmonize Dengue Nomenclature and Classification.

Lize Cuypers, Pieter J K Libin, Peter Simmonds, Ann Nowé, Jorge Muñoz-Jordán, Luiz Carlos Junior Alcantara, Anne-Mieke Vandamme, Gilberto A Santiago, Kristof Theys

Abstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lize CuypersDepartment of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium. lize.cuypers@kuleuven.be.ORCID 0000-0002-9433-8752
Pieter J K LibinDepartment of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium. pieter.libin@vub.ac.be.ORCID 0000-0003-3906-758X
Peter SimmondsNuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. peter.simmonds@ndm.ox.ac.uk.ORCID 0000-0002-7964-4700
Ann NowéArtificial Intelligence Lab, Department of Computer Science, Vrije Universiteit Brussel, 1050 Brussels, Belgium. ann.nowe@ai.vub.ac.be.
Jorge Muñoz-JordánDivision of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, PR 00920, USA. jmunoz@cdc.gov.
Luiz Carlos Junior AlcantaraLaboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, 21040-360 Rio de Janeiro, Brazil. luiz.alcantara@ioc.fiocruz.br.
Anne-Mieke VandammeDepartment of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium. annemie.vandamme@kuleuven.be.ORCID 0000-0002-6594-2766
Gilberto A SantiagoDivision of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, PR 00920, USA. gsantiago@cdc.gov.
Kristof TheysDepartment of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium. kristof.theys@kuleuven.be.ORCID 0000-0003-0242-7000

Funding

Welcome Trust WT108418AIA
6 · The paper itself

Abstract

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV's current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies.

Indexed as

DengueDengue VirusGenetic VariationGenotypeHumansPhylogenyTerminology as Topicclassificationdengue virusdiversitynomenclature

Identifiers

PMID30340326
PMCPMC6213058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.