ArticleJournal of affective disorders2019
Diverse pathophysiological processes converge on network disruption in mania.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Activation network mapping for integration of heterogeneous fMRI findings.Nature human behaviour · 2022Pooled it
- Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder.Molecular psychiatry · 2024Article
- Provincial and connector qualities of somatosensory brain network hubs in bipolar disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Functional connectivity alterations of the somatomotor network in euthymic bipolar disorder.Neuroscience applied · 2023Article
- Connectivity Alterations in Emotional and Cognitive Networks During a Manic State Induced by Direct Electrical Stimulation.Brain topography · 2022Article
- Grey and white matter alteration in euthymic children with bipolar disorder: a combined source-based morphometry (SBM) and voxel-based morphometry (VBM) study.Brain imaging and behavior · 2022Article
- Tracing the psychopathology of bipolar disorder to the functional architecture of intrinsic brain activity and its neurotransmitter modulation: a three-dimensional model.Molecular psychiatry · 2022Review
- Functional neuroanatomy of mania.Translational psychiatry · 2022Review
- A unified model of the pathophysiology of bipolar disorder.Molecular psychiatry · 2022Review
- Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study.European archives of psychiatry and clinical neuroscience · 2021Article
- Lesion network mapping predicts post-stroke behavioural deficits and improves localization.Brain : a journal of neurology · 2021Article
- Lesions causing hallucinations localize to one common brain network.Molecular psychiatry · 2021Article
- Mapping mania symptoms based on focal brain damage.The Journal of clinical investigation · 2020Article
- A case report of mania with abnormal cerebral blood flow and cognitive impairment 24 years after head trauma.Annals of general psychiatry · 2020Article
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7 authors.
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Abstract
backgroundNeuroimaging of psychiatric disease is challenged by the difficulty of establishing the causal role of neuroimaging abnormalities. Lesions that cause mania present a unique opportunity to understand how brain network disruption may cause mania in both lesions and in bipolar disorder.
methodsA literature search revealed 23 case reports with imaged lesions that caused mania in patients without history of bipolar disorder. We traced these lesions and examined resting-state functional Magnetic Resonance Imaging (rsfMRI) connectivity to these lesions and control lesions to find networks that would be disrupted specifically by mania-causing lesions. The results were then used as regions-of-interest to examine rsfMRI connectivity in patients with bipolar disorder (n = 16) who underwent imaging longitudinally across states of both mania and euthymia alongside a cohort of healthy participants scanned longitudinally. We then sought to replicate these results in independent cohorts of manic (n = 26) and euthymic (n = 21) participants with bipolar disorder.
resultsMania-inducing lesions overlap significantly in network connectivity. Mania-causing lesions selectively disrupt networks that include orbitofrontal cortex, dorsolateral prefrontal cortex, and temporal lobes. In bipolar disorder, the manic state was reflected in strong, significant, and specific disruption in network communication between these regions and regions implicated in bipolar pathophysiology: the amygdala and ventro-lateral prefrontal cortex. LIMITATIONS: There was heterogeneity in the clinical characterization of mania causing lesions.
conclusionsLesions causing mania demonstrate shared and specific network disruptions. These disruptions are also observed in bipolar mania and suggest a convergence of multiple disorders on shared circuit dysfunction to cause mania.
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