Evidence map›Paper›PMID 30340041›Full record

ArticleCell2018

The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study.

David Terburg, Diego Scheggia, Rodrigo Triana Del Rio, Floris Klumpers, Alexandru Cristian Ciobanu, Barak Morgan, Estrella R Montoya, Peter A Bos, Gion Giobellina, Erwin H van den Burg and 4 more

Abstract read
In one paragraph

Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

David TerburgDepartment of Psychology, Utrecht University, Utrecht, the Netherlands; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. Electronic address: d.terburg@uu.nl.
Diego ScheggiaCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland.
Rodrigo Triana Del RioCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland.
Floris KlumpersDonders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Alexandru Cristian CiobanuCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland.
Barak MorganGlobal Risk Governance Program, Institute for Safety Governance and Criminology, Law Faculty, University of Cape Town, Cape Town, South Africa.
Estrella R MontoyaDepartment of Psychology, Utrecht University, Utrecht, the Netherlands.
Peter A BosDepartment of Psychology, Utrecht University, Utrecht, the Netherlands.
Gion GiobellinaCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland.
Erwin H van den BurgCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland.
Beatrice de GelderDepartment of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, Cape Town, South Africa.
Ron StoopCenter for Psychiatric Neuroscience, Lausanne University and University Hospital Center, Lausanne, Switzerland. Electronic address: ron.stoop@unil.ch.
Jack van HonkDepartment of Psychology, Utrecht University, Utrecht, the Netherlands; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Funding

HSRD VA CDP 13-004
6 · The paper itself

Abstract

Rodent research delineates how the basolateral amygdala (BLA) and central amygdala (CeA) control defensive behaviors, but translation of these findings to humans is needed. Here, we compare humans with natural-selective bilateral BLA lesions to rats with a chemogenetically silenced BLA. We find, across species, an essential role for the BLA in the selection of active escape over passive freezing during exposure to imminent yet escapable threat (T

Indexed as

Escape ReactionAdultAnimalsBasolateral Nuclear ComplexFearFemaleFreezing Reaction, CatalepticHumansMaleRatsRats, Sprague-DawleyReflex, StartleSpecies Specificitybasolateral amygdalacentral amygdalaDREADDescapefearfreezingoxytocinstartle reflexthreatUrbach Wiethe

Identifiers

PMID30340041
PMCPMC6198024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.