ReviewCurrent opinion in psychology2019
Polygenic risk scoring and prediction of mental health outcomes.
Review in Current opinion in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Polygenic Scores for ADHD: A Meta-Analysis.Research on child and adolescent psychopathology · 2021Pooled it
- Polygenic risk score for neurodevelopmental disorders and cognitive impairment at long-term follow-up of first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies.American journal of human genetics · 2026Article
- Multisystem regulation of reward and addiction: beyond the dopaminergic system.Frontiers in pharmacology · 2026Review
- The impact of collider bias on genetic prediction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A machine learning framework for classifying dementia risk in mild cognitive impairment: evidence from a Korean genome-wide association study cohort.Alzheimer's research & therapy · 2025Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Psychiatric polygenic risk scores: Experience, hope for utility, and concerns among child and adolescent psychiatrists.Psychiatry research · 2024Article
- Role of polygenic risk scores in the association between chronotype and health risk behaviors.BMC psychiatry · 2023Article
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Polygenic risk scores for schizophrenia and major depression are associated with socio-economic indicators of adversity in two British community samples.Translational psychiatry · 2022Article
- Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study.Epidemiology and psychiatric sciences · 2022Article
- Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- A Polygenic Approach to Understanding Resilience to Peer Victimisation.Behavior genetics · 2022Article
- Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction.American journal of human genetics · 2021Article
- Phenotypic and genetic markers of psychopathology in a population-based sample of older adults.Translational psychiatry · 2021Article
- Phenotypically independent profiles relevant to mental health are genetically correlated.Translational psychiatry · 2021Article
- Multisite schizophrenia classification by integrating structural magnetic resonance imaging data with polygenic risk score.NeuroImage. Clinical · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Psychiatric conditions are highly polygenic, meaning that genetic risk arises from many hundreds or thousands of genetic variants. Psychiatric genomics and psychological science are increasingly using polygenic risk scoring-the integration of all common genetic variant effects into a single risk metric-to model latent risk and to predict mental health outcomes. This review discusses the use of these scores in psychology and psychiatry to date, important methodological considerations, and potential of scoring methods for informing psychological science. Polygenic risk scores can easily be added to environmental and behavioral genetic models of latent risk, making them desirable metrics for use in psychological research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.