ArticleNeurobiology of aging2019
Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- APOE ε4 carriage is associated with olfactory-hippocampal tract functional connectivity.Brain imaging and behavior · 2026Article
- APOE ε4-related differences in brain structure, function, and connectivity at midlife: A scoping review.The journal of prevention of Alzheimer's disease · 2025Article
- Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.Brain : a journal of neurology · 2025Article
- Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure.Translational psychiatry · 2024Review
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Genetic risk factors of Alzheimer's Disease disrupt resting-state functional connectivity in cognitively intact young individuals.Journal of neurology · 2023Article
- White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways.Brain and behavior · 2023Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Tract-specific differences in white matter microstructure between young adultNeuroimage. Reports · 2022Article
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife.JAMA network open · 2022Article
- Evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult APOE E4 carriers: A resting stateNeuroimage. Reports · 2021Article
- Functional co-activation of the default mode network in APOE ε4-carriers: A replication study.NeuroImage · 2021Article
- Different posterior hippocampus and default mode network modulation in young APOE ε4 carriers: a functional connectome-informed phenotype longitudinal study.Molecular neurobiology · 2021Article
- APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.Journal of Alzheimer's disease : JAD · 2021Article
- Mid age APOE ε4 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions.Scientific reports · 2020Article
- Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4.Frontiers in aging neuroscience · 2020Article
- Aberrant Brain Spontaneous Activity and Synchronization in Type 2 Diabetes Mellitus Patients: A Resting-State Functional MRI Study.Frontiers in aging neuroscience · 2020Article
- Alzheimer's pathology targets distinct memory networks in the ageing brain.Brain : a journal of neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Young adult APOE-ε4 carriers show increased activity in posterior regions of the default mode network (pDMN), but how this is related to structural connectivity is unknown. Thirty young adults (one half of whom were APOE-ε4 carriers; mean age 20 years) were scanned using both diffusion and functional magnetic resonance imaging. The parahippocampal cingulum bundle (PHCB)-which links the pDMN and the medial temporal lobe-was manually delineated in individual participants using deterministic tractography. Measures of tract microstructure (mean diffusivity and fractional anisotropy) were then extracted from these tract delineations. APOE-ε4 carriers had lower mean diffusivity and higher fractional anisotropy relative to noncarriers in PHCB, but not in a control tract (the inferior longitudinal fasciculus). Furthermore, PHCB microstructure was selectively associated with pDMN (and medial temporal lobe) activity during a scene discrimination task known to be sensitive to Alzheimer's disease. These findings are consistent with a lifespan view of Alzheimer's disease risk, where early-life, connectivity-related changes in specific, vulnerable "hubs" (e.g., pDMN) lead to increased neural activity. Critically, such changes may reflect reduced network efficiency/flexibility in APOE-ε4 carriers, which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early amyloid-β deposition in later life.
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